Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapD-relB/-
Location 878812..879469 Replicon chromosome
Accession NZ_CP011482
Organism Helicobacter pylori strain L7

Toxin (Protein)


Gene name VapD Uniprot ID A0A1A9GY66
Locus tag AA971_RS04190 Protein ID WP_064432318.1
Coordinates 878812..879096 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1A9GWT7
Locus tag AA971_RS04195 Protein ID WP_064432319.1
Coordinates 879077..879469 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA971_RS04170 875367..876134 - 768 WP_000242353.1 ABC transporter ATP-binding protein -
AA971_RS04175 876134..877114 - 981 WP_000921458.1 iron ABC transporter permease -
AA971_RS04180 877107..877949 - 843 WP_064432317.1 SDR family oxidoreductase -
AA971_RS04185 878089..878613 + 525 WP_050831586.1 acyl-CoA thioesterase -
AA971_RS04190 878812..879096 - 285 WP_064432318.1 endoribonuclease VapD Toxin
AA971_RS04195 879077..879469 - 393 WP_064432319.1 hypothetical protein Antitoxin
AA971_RS04200 879917..881632 - 1716 Protein_821 hypothetical protein -
AA971_RS04215 882016..882674 + 659 Protein_822 hypothetical protein -
AA971_RS04220 882625..883737 - 1113 WP_064432321.1 hydrogenase formation protein HypD -
AA971_RS04225 883737..883976 - 240 WP_064432322.1 HypC/HybG/HupF family hydrogenase formation chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11090.60 Da        Isoelectric Point: 5.1974

>T54291 WP_064432318.1 NZ_CP011482:c879096-878812 [Helicobacter pylori]
MYALAFDLKIEILKKEYGEPYNKAHDDLRQELELLGFENTQGSVYVNYSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKS

Download         Length: 285 bp

>T54291 NZ_CP011482:c879096-878812 [Helicobacter pylori]
ATGTATGCTTTAGCGTTTGATTTAAAGATTGAGATTTTAAAAAAAGAATACGGAGAACCCTACAATAAAGCCCATGATGA
TTTAAGGCAAGAATTAGAGCTATTAGGGTTTGAAAACACTCAAGGGAGCGTTTATGTTAATTATTCTAAAGAAAACACTC
TAGCACAAGTCTATAAAGCGATCAATAAACTCTCTCAAATTGAGTGGTTTAAAAAGTCTGTTAGGGATATTAGAGCGTTT
AAGGTAGAGGACTTTAGCGATTTCACTGAGATTGTGAAATCCTAG

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15164.20 Da        Isoelectric Point: 7.7115

>AT54291 WP_064432319.1 NZ_CP011482:c879469-879077 [Helicobacter pylori]
MPNTTAKKDYTKYSEKQLFNLIHQLERKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKNDCCL
GNKTPNLETQQAMRDALNGVNLTQIDSLDDLTNELKRENSKGFENVCFSV

Download         Length: 393 bp

>AT54291 NZ_CP011482:c879469-879077 [Helicobacter pylori]
ATGCCTAACACCACCGCCAAAAAAGACTACACAAAATACAGCGAAAAACAGCTTTTTAATCTAATCCATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCGTTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGACGATAAAAATGATTGCTGTTTG
GGGAATAAGACCCCAAACCTTGAAACGCAACAAGCCATGAGAGACGCGTTAAATGGGGTTAATCTCACTCAAATTGATAG
TTTAGATGATCTTACAAACGAGTTAAAAAGAGAAAATAGTAAAGGTTTTGAAAATGTATGCTTTAGCGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A9GY66

Antitoxin

Source ID Structure
AlphaFold DB A0A1A9GWT7

References