Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1783679..1784311 Replicon chromosome
Accession NZ_CP011477
Organism Spongiibacter sp. IMCC21906

Toxin (Protein)


Gene name vapC Uniprot ID A0A0F7M1P1
Locus tag IMCC21906_RS08165 Protein ID WP_047011756.1
Coordinates 1783679..1784077 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0F7M2P4
Locus tag IMCC21906_RS08170 Protein ID WP_047011757.1
Coordinates 1784078..1784311 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMCC21906_RS08140 1778906..1779889 - 984 WP_047013261.1 ubiquinol oxidase subunit II -
IMCC21906_RS08145 1780044..1781363 + 1320 WP_047011752.1 MFS transporter -
IMCC21906_RS08150 1781458..1781736 - 279 WP_047011753.1 hypothetical protein -
IMCC21906_RS08155 1781808..1782665 - 858 WP_047011754.1 EAL domain-containing protein -
IMCC21906_RS08160 1783176..1783568 + 393 WP_082117414.1 NUDIX hydrolase -
IMCC21906_RS08165 1783679..1784077 - 399 WP_047011756.1 tRNA(fMet)-specific endonuclease VapC Toxin
IMCC21906_RS08170 1784078..1784311 - 234 WP_047011757.1 antitoxin Antitoxin
IMCC21906_RS08180 1784896..1786773 + 1878 WP_052763442.1 response regulator -
IMCC21906_RS08185 1786791..1787162 + 372 WP_047011758.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14757.00 Da        Isoelectric Point: 7.0628

>T54288 WP_047011756.1 NZ_CP011477:c1784077-1783679 [Spongiibacter sp. IMCC21906]
MLKHMLDTKIAIYVIKRRPIEIMPTFGAHAGQLCLSTITLAELLHGVEKSTRPEQNRQALEDFVSRLEVLEYGAKAAGHY
GDIRADLEREGKVIGVNDLHIAGHARSEGLVLVTNNLGEFERVKGLRTENWV

Download         Length: 399 bp

>T54288 NZ_CP011477:c1784077-1783679 [Spongiibacter sp. IMCC21906]
ATGCTCAAGCACATGCTAGATACCAAGATTGCTATCTATGTTATCAAGCGCCGTCCGATAGAGATCATGCCGACCTTCGG
CGCCCACGCGGGTCAGCTTTGCCTTAGCACTATCACCCTGGCGGAGCTTCTTCATGGCGTGGAGAAAAGTACCAGGCCGG
AACAAAACCGTCAGGCATTGGAGGACTTTGTTTCACGGCTAGAGGTGCTGGAATATGGGGCCAAAGCAGCGGGGCATTAT
GGCGATATTCGTGCCGACCTGGAGCGCGAGGGTAAGGTGATTGGCGTCAACGATCTACATATTGCAGGCCACGCCCGAAG
TGAGGGATTGGTTCTTGTCACCAATAATCTCGGTGAATTCGAGCGAGTGAAAGGACTCCGAACCGAGAACTGGGTTTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8707.63 Da        Isoelectric Point: 4.5258

>AT54288 WP_047011757.1 NZ_CP011477:c1784311-1784078 [Spongiibacter sp. IMCC21906]
MSTGTVFENNRTQAVRLPADSRFPDGIKKVNVRVQGKDRIISPLENTWDSFFLEGEAVTDDFMDERASQDQTPRGAF

Download         Length: 234 bp

>AT54288 NZ_CP011477:c1784311-1784078 [Spongiibacter sp. IMCC21906]
ATGTCTACAGGCACCGTATTTGAAAACAACCGCACCCAGGCAGTTAGACTTCCGGCTGATTCACGCTTTCCTGATGGAAT
CAAGAAAGTAAACGTTCGGGTTCAGGGCAAAGACCGGATCATTTCGCCGCTCGAGAATACCTGGGATAGCTTTTTCCTGG
AGGGCGAGGCCGTAACCGATGATTTTATGGATGAGCGGGCGAGCCAGGATCAAACGCCGAGGGGAGCGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F7M1P1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F7M2P4

References