Detailed information of TA system TA054286

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 750357..750900
• Replicon: chromosome
• Accession: NZ_CP011477
• Organism: Spongiibacter sp. IMCC21906

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IMCC21906_RS16585
• Protein ID: WP_082117337.1
• Coordinates: 750357..750629 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0F7LYL4
• Locus tag: IMCC21906_RS03430
• Protein ID: WP_047011000.1
• Coordinates: 750622..750900 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IMCC21906_RS16960	746900..747313	-	414	WP_197085942.1	tyrosine-type recombinase/integrase	-
IMCC21906_RS03410	747497..748213	+	717	WP_047010997.1	hypothetical protein	-
IMCC21906_RS03420	748770..749849	+	1080	WP_156165977.1	hypothetical protein	-
IMCC21906_RS03425	749896..750423	+	528	WP_197085943.1	transposase	-
IMCC21906_RS16585	750357..750629	-	273	WP_082117337.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
IMCC21906_RS03430	750622..750900	-	279	WP_047011000.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IMCC21906_RS03435	751045..751419	+	375	WP_052763345.1	hypothetical protein	-
IMCC21906_RS03440	752076..753338	+	1263	WP_047011002.1	serine hydroxymethyltransferase	-
IMCC21906_RS03445	753449..753928	+	480	WP_047011003.1	transcriptional regulator NrdR	-
IMCC21906_RS03450	753925..755049	+	1125	WP_047011004.1	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	-
IMCC21906_RS03455	755058..755711	+	654	WP_047011005.1	riboflavin synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-82)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10372.03 Da
• Isoelectric Point: 8.0613

>T54286 WP_082117337.1 NZ_CP011477:c750629-750357 [Spongiibacter sp. IMCC21906]
MLKLEYSTQFKKDFKKIAKLSIPDIVEVGHVIKQLQLGETLPEKYVDHSLSGDWQNYRDCHVKPDLVLIYKIDSNSLKLA
RIGTHSELFG

Nucleotide

• Length: 273 bp

>T54286 NZ_CP011477:c750629-750357 [Spongiibacter sp. IMCC21906]
ATGCTTAAACTTGAATATTCTACGCAATTTAAAAAAGACTTTAAGAAGATAGCAAAACTTTCAATACCCGACATTGTTGA
AGTTGGTCACGTGATAAAACAACTCCAGCTTGGTGAAACCTTGCCCGAAAAATACGTTGACCACTCTCTATCTGGTGACT
GGCAAAACTATCGAGATTGTCACGTTAAACCAGATCTGGTTTTAATTTATAAAATTGATTCCAACTCCTTAAAACTTGCA
AGAATTGGAACGCATAGTGAGTTGTTCGGATAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 9948.49 Da
• Isoelectric Point: 5.1086

>AT54286 WP_047011000.1 NZ_CP011477:c750900-750622 [Spongiibacter sp. IMCC21906]
MKTEMLSTRIDSNTKLAFTSVCEDMGISPSQAIKLFAKAVVNYGGIPFELKVKQPNKLTAAAIDEIEAGKANTAKDVEAL
FSDLNIEKLKDA

Nucleotide

• Length: 279 bp

>AT54286 NZ_CP011477:c750900-750622 [Spongiibacter sp. IMCC21906]
ATGAAGACTGAAATGTTAAGTACACGCATAGACAGTAATACCAAGTTAGCCTTCACTAGCGTGTGCGAGGATATGGGCAT
TAGCCCCTCCCAAGCTATAAAACTATTTGCAAAGGCGGTAGTAAATTATGGAGGAATACCTTTTGAGCTTAAAGTGAAAC
AGCCTAACAAGCTTACCGCAGCAGCTATAGACGAGATTGAAGCAGGTAAGGCCAACACAGCTAAAGATGTTGAGGCGCTA
TTTAGTGATTTAAACATCGAAAAGCTAAAAGATGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0F7LYL4