Detailed information of TA system TA054280

Bioinformatically predicted

Overview

TA module

• Type: VII
• Classification (family/domain): HepT-MntA/HepT(toxin)
• Location: 3582764..3583656
• Replicon: chromosome
• Accession: NZ_CP011456
• Organism: Anabaena sp. WA102 isolate

Toxin (Protein)

• Gene name: hepT
• Uniprot ID: -
• Locus tag: AA650_RS15565
• Protein ID: WP_053539692.1
• Coordinates: 3583213..3583656 (+)
• Length: 148 a.a.

Antitoxin (Protein)

• Gene name: mntA
• Uniprot ID: A0A0K2M0Z3
• Locus tag: AA650_RS15560
• Protein ID: WP_053539691.1
• Coordinates: 3582764..3583216 (+)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AA650_RS15535	3579536..3579730	+	195	WP_039205087.1	potassium-transporting ATPase subunit F	-
AA650_RS15540	3579730..3580344	+	615	WP_053539688.1	K(+)-transporting ATPase subunit C	-
AA650_RS15545	3580327..3580653	-	327	WP_052150108.1	hypothetical protein	-
AA650_RS15550	3581134..3582006	-	873	WP_053539689.1	WYL domain-containing protein	-
AA650_RS15555	3582467..3582649	+	183	WP_081424378.1	hypothetical protein	-
AA650_RS15560	3582764..3583216	+	453	WP_053539691.1	nucleotidyltransferase domain-containing protein	Antitoxin
AA650_RS15565	3583213..3583656	+	444	WP_053539692.1	DUF86 domain-containing protein	Toxin
AA650_RS15570	3583649..3586378	+	2730	WP_053539693.1	CRISPR-associated protein Csc3	-
AA650_RS15575	3586407..3587432	+	1026	WP_053539694.1	type I-D CRISPR-associated protein Cas7/Csc2	-
AA650_RS15580	3587436..3588194	+	759	WP_053539695.1	type I-D CRISPR-associated protein Cas5/Csc1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease HepT-like (18-133)

Antitoxin

• Polymerase beta, nucleotidyltransferase (19-111)

Sequences

Toxin

Protein

• Length: 148 a.a.
• Molecular weight: 17109.54 Da
• Isoelectric Point: 4.5034

>T54280 WP_053539692.1 NZ_CP011456:3583213-3583656 [Anabaena sp. WA102]
MNNIDSEIVLSRLRLITKYYNTLVEFNSLSLDEFLGDFRQQLIVERLLQLMTQAAIDINDHILSKLKSGKSYTNFEAFIE
LGKYQILTPELAKQIAPSSGLRNRLVHEYDDIDPNQVFMAISFALQQYPLYVRQINSYLITLEEEND

Nucleotide

• Length: 444 bp

>T54280 NZ_CP011456:3583213-3583656 [Anabaena sp. WA102]
ATGAATAATATAGATTCTGAAATAGTTTTATCAAGACTAAGGTTAATTACCAAATATTACAACACATTAGTAGAATTTAA
TTCTCTGAGTCTTGATGAATTTTTAGGTGATTTTCGTCAACAACTAATTGTAGAAAGACTATTGCAATTAATGACTCAAG
CCGCAATAGACATCAATGATCATATATTGTCAAAACTCAAATCTGGAAAGTCTTACACTAATTTTGAGGCTTTTATTGAA
TTAGGTAAATATCAAATTCTTACTCCTGAACTAGCAAAACAAATTGCGCCATCATCAGGTTTAAGAAATCGTTTGGTTCA
TGAATATGATGATATAGATCCGAATCAGGTTTTCATGGCAATTAGTTTTGCATTACAGCAATATCCGCTTTATGTTAGAC
AAATCAACTCTTATTTAATTACATTGGAAGAAGAAAATGATTAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 17371.03 Da
• Isoelectric Point: 4.8243

>AT54280 WP_053539691.1 NZ_CP011456:3582764-3583216 [Anabaena sp. WA102]
MQNNTPTITELQELSSQIPEKIPYLKMLVLFGSRATGKTKANSDWDFAVLYDEEKRQNYIANNIAVLFELPIVIGEVLQI
NPDIIDIVELNKCSWLISHFVARDGIMLYEKFTGQFNDFCLNSLKAESELKKFRKEQQRIIEIELNKWGA

Nucleotide

• Length: 453 bp

>AT54280 NZ_CP011456:3582764-3583216 [Anabaena sp. WA102]
ATGCAAAACAATACTCCCACAATTACAGAACTTCAAGAATTATCCTCACAAATTCCTGAGAAAATACCTTACTTAAAAAT
GTTAGTTTTATTTGGTTCTAGAGCAACTGGTAAAACTAAAGCTAATAGTGACTGGGATTTTGCAGTTTTATATGATGAAG
AAAAACGTCAGAATTACATAGCAAATAATATTGCTGTTTTATTTGAACTGCCAATTGTGATTGGTGAAGTTTTACAAATT
AATCCTGATATTATAGATATTGTAGAACTAAATAAATGTTCTTGGTTAATTAGTCATTTTGTAGCGCGTGATGGAATTAT
GTTATATGAAAAATTTACTGGACAATTTAATGATTTTTGCTTAAATTCCTTAAAAGCTGAATCAGAGTTAAAGAAATTTC
GTAAAGAGCAACAACGAATTATTGAAATAGAGTTAAATAAGTGGGGAGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A0K2M0Z3