Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 3368426..3368927 Replicon chromosome
Accession NZ_CP011456
Organism Anabaena sp. WA102 isolate

Toxin (Protein)


Gene name relB Uniprot ID A0A0K2M0U4
Locus tag AA650_RS14505 Protein ID WP_053539552.1
Coordinates 3368673..3368927 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2M0G3
Locus tag AA650_RS14500 Protein ID WP_039201895.1
Coordinates 3368426..3368680 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA650_RS14455 3363448..3363834 + 387 WP_053539544.1 type II toxin-antitoxin system VapC family toxin -
AA650_RS14460 3364180..3364434 + 255 WP_168636756.1 type II toxin-antitoxin system VapC family toxin -
AA650_RS27990 3364434..3364589 + 156 WP_168636757.1 hypothetical protein -
AA650_RS14465 3364860..3365225 - 366 WP_199924258.1 DUF559 domain-containing protein -
AA650_RS14475 3365847..3366062 + 216 WP_053539548.1 hypothetical protein -
AA650_RS14480 3366014..3366340 + 327 WP_053539549.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
AA650_RS14490 3366741..3366944 + 204 WP_028091145.1 type II toxin-antitoxin system HicB family antitoxin -
AA650_RS26640 3366941..3367102 + 162 WP_081424229.1 type II toxin-antitoxin system HicA family toxin -
AA650_RS27995 3367221..3367325 + 105 WP_168636808.1 type II toxin-antitoxin system HicA family toxin -
AA650_RS14495 3367651..3368208 + 558 WP_053539551.1 Uma2 family endonuclease -
AA650_RS14500 3368426..3368680 + 255 WP_039201895.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AA650_RS14505 3368673..3368927 + 255 WP_053539552.1 Txe/YoeB family addiction module toxin Toxin
AA650_RS14510 3368894..3369337 - 444 WP_081424230.1 polysaccharide deacetylase family protein -
AA650_RS14515 3369439..3370260 + 822 WP_053539553.1 RnfABCDGE type electron transport complex subunit D -
AA650_RS14520 3370291..3371664 + 1374 WP_053539554.1 DUF2330 domain-containing protein -
AA650_RS26645 3372043..3372289 + 247 Protein_2919 hypothetical protein -
AA650_RS14525 3372728..3373858 - 1131 WP_053539555.1 CO2 hydration protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-80)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10002.40 Da        Isoelectric Point: 7.9465

>T54279 WP_053539552.1 NZ_CP011456:3368673-3368927 [Anabaena sp. WA102]
MRKLAWGSKAWKDYLYWQSQDKKTLKRINQLIQDTLSDPFEGIGKPEPLKENLSGFWSRRIDETNRLIYAIDDDYLTIIS
YCNV

Download         Length: 255 bp

>T54279 NZ_CP011456:3368673-3368927 [Anabaena sp. WA102]
ATGCGTAAATTAGCTTGGGGTAGTAAAGCGTGGAAAGATTATCTTTATTGGCAATCTCAAGACAAGAAAACTTTAAAAAG
AATCAATCAACTTATCCAAGATACTTTATCAGATCCCTTTGAAGGAATCGGTAAACCCGAACCTTTGAAAGAGAATTTGT
CAGGTTTTTGGTCTCGCCGTATTGATGAAACAAATCGTCTTATTTATGCTATCGATGATGATTATCTGACAATTATTTCA
TATTGTAATGTTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9454.60 Da        Isoelectric Point: 4.5836

>AT54279 WP_039201895.1 NZ_CP011456:3368426-3368680 [Anabaena sp. WA102]
MNIVNFSEARNNFKSVLDTVANDKNCTVIVRRDAEDAVVMSKSYYDSLMETVYLLKSPANAQHLEEAIAEYKAGKTQEHD
LIDA

Download         Length: 255 bp

>AT54279 NZ_CP011456:3368426-3368680 [Anabaena sp. WA102]
ATGAACATCGTCAACTTTAGCGAAGCAAGAAACAATTTTAAATCCGTACTAGATACAGTGGCCAATGATAAAAACTGTAC
CGTCATTGTTAGAAGAGATGCGGAAGATGCTGTAGTCATGTCTAAAAGTTATTATGACAGTCTGATGGAAACAGTTTATC
TGTTAAAATCCCCTGCTAATGCTCAACATTTAGAAGAAGCGATCGCCGAATACAAAGCAGGGAAAACACAAGAACACGAT
TTAATCGATGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2M0U4

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2M0G3

References