Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 1848934..1849563 Replicon chromosome
Accession NZ_CP011456
Organism Anabaena sp. WA102 isolate

Toxin (Protein)


Gene name vapC Uniprot ID A0A0K2LXD0
Locus tag AA650_RS08095 Protein ID WP_053538624.1
Coordinates 1848934..1849335 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0K2LXN3
Locus tag AA650_RS08100 Protein ID WP_053538625.1
Coordinates 1849336..1849563 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA650_RS08065 1845286..1845615 + 330 WP_039203110.1 thioredoxin -
AA650_RS08070 1845628..1847127 - 1500 WP_053538619.1 family 10 glycosylhydrolase -
AA650_RS08075 1847160..1847339 - 180 Protein_1612 ISAzo13 family transposase -
AA650_RS08080 1847415..1847579 - 165 WP_168634702.1 hypothetical protein -
AA650_RS08085 1847989..1848390 - 402 WP_053538622.1 type II toxin-antitoxin system VapC family toxin -
AA650_RS08090 1848378..1848599 - 222 WP_053538623.1 hypothetical protein -
AA650_RS08095 1848934..1849335 - 402 WP_053538624.1 type II toxin-antitoxin system VapC family toxin Toxin
AA650_RS08100 1849336..1849563 - 228 WP_053538625.1 virulence factor Antitoxin
AA650_RS27715 1849959..1850060 - 102 WP_199924403.1 type II toxin-antitoxin system HicB family antitoxin -
AA650_RS27720 1850306..1850473 - 168 WP_168466228.1 hypothetical protein -
AA650_RS08110 1850477..1850950 - 474 Protein_1620 type II toxin-antitoxin system VapC family toxin -
AA650_RS08115 1851649..1852566 - 918 WP_053538626.1 hypothetical protein -
AA650_RS08120 1852711..1853991 - 1281 WP_053538627.1 serine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15095.69 Da        Isoelectric Point: 5.8665

>T54275 WP_053538624.1 NZ_CP011456:c1849335-1848934 [Anabaena sp. WA102]
MQYLLDTNICIYLIRQKPEKVIARFQTLSISDIGISSITVAELEYGVYKSQQQEKNKNALMQFLLPLEIIEFSQNAAVIY
GCIRSDLERKGLVIGLMDMLIAAHAMSLGVTLVTNNIREFSRIPKLSLENWAE

Download         Length: 402 bp

>T54275 NZ_CP011456:c1849335-1848934 [Anabaena sp. WA102]
ATGCAATATCTTCTCGATACTAATATCTGTATTTATCTGATTAGGCAAAAACCAGAAAAAGTTATAGCACGATTTCAAAC
CTTGTCAATTTCTGATATTGGCATTTCTTCCATTACCGTTGCTGAATTAGAATATGGAGTTTATAAAAGTCAGCAACAAG
AGAAAAATAAAAATGCCCTCATGCAGTTTTTACTTCCTTTAGAAATTATTGAATTTAGTCAAAATGCAGCAGTAATTTAT
GGATGTATTAGAAGTGATTTAGAAAGAAAAGGGCTTGTAATTGGATTAATGGATATGTTAATTGCTGCTCATGCAATGAG
CTTAGGTGTTACTCTCGTTACTAACAATATCCGCGAATTTTCTCGCATTCCTAAACTCTCGTTAGAAAATTGGGCAGAGT
AA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8630.89 Da        Isoelectric Point: 4.4535

>AT54275 WP_053538625.1 NZ_CP011456:c1849563-1849336 [Anabaena sp. WA102]
MNTAKLCSDGTHQMVILPTDFKMTGTEVYVKKIGNAIILISKDNSWQTLIDSLDQFSDDFMMTRDQLPIDKREEF

Download         Length: 228 bp

>AT54275 NZ_CP011456:c1849563-1849336 [Anabaena sp. WA102]
ATGAATACAGCTAAACTTTGCAGTGACGGTACTCATCAAATGGTGATATTACCAACAGATTTTAAAATGACAGGTACTGA
AGTCTATGTTAAAAAAATTGGTAATGCCATTATTCTTATTAGTAAAGATAATTCTTGGCAAACTCTAATTGATAGTTTAG
ACCAATTTTCTGATGATTTTATGATGACTAGAGATCAACTTCCTATTGATAAAAGAGAGGAGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2LXD0

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2LXN3

References