Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1543961..1544751 Replicon chromosome
Accession NZ_CP011456
Organism Anabaena sp. WA102 isolate

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0K2LWM2
Locus tag AA650_RS06590 Protein ID WP_053538438.1
Coordinates 1543961..1544464 (-) Length 168 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A0K2LWK8
Locus tag AA650_RS06595 Protein ID WP_053538439.1
Coordinates 1544461..1544751 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA650_RS06570 1539666..1540448 - 783 WP_039201961.1 ABC transporter permease -
AA650_RS06575 1540822..1541427 + 606 WP_039201960.1 VTT domain-containing protein -
AA650_RS06580 1541528..1543246 + 1719 WP_053538436.1 ABC transporter ATP-binding protein/permease -
AA650_RS06590 1543961..1544464 - 504 WP_053538438.1 GNAT family N-acetyltransferase Toxin
AA650_RS06595 1544461..1544751 - 291 WP_053538439.1 DUF1778 domain-containing protein Antitoxin
AA650_RS06600 1545071..1545589 + 519 WP_053538440.1 DUF29 domain-containing protein -
AA650_RS06605 1545637..1546536 + 900 WP_053538441.1 M48 family metallopeptidase -
AA650_RS06610 1546949..1547449 + 501 WP_053538442.1 2TM domain-containing protein -
AA650_RS06615 1547573..1548157 + 585 WP_053538443.1 Uma2 family endonuclease -
AA650_RS06620 1548190..1548414 - 225 WP_053538444.1 addiction module protein -
AA650_RS06625 1548692..1549702 + 1011 WP_053538445.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(25-146)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 168 a.a.        Molecular weight: 18144.96 Da        Isoelectric Point: 7.2131

>T54274 WP_053538438.1 NZ_CP011456:c1544464-1543961 [Anabaena sp. WA102]
MSLTPPETLSSHHSCSDFSCGIASLDDWLKRRAYTNQISGATRTFVLCVDNRVVGYYALASGAISVQSALGKFRRNMPDP
IPVVILARLAIVAIDSSYQSQGLGRALFRDAALRVVQAADTIGIRGIIVHAISEEAKDFYLALGFILSPLEPMTLMITLN
DLRDSIT

Download         Length: 504 bp

>T54274 NZ_CP011456:c1544464-1543961 [Anabaena sp. WA102]
ATGAGTTTAACACCACCTGAAACTCTCTCTAGTCACCACTCCTGCTCTGATTTTTCCTGTGGAATTGCTTCTCTTGATGA
TTGGTTAAAACGTCGAGCTTATACCAATCAAATCAGTGGTGCAACTAGAACTTTTGTTCTTTGCGTTGACAATAGAGTAG
TTGGGTATTATGCCCTGGCTTCTGGAGCGATTAGTGTACAATCAGCCTTAGGTAAATTTCGGCGAAATATGCCTGACCCC
ATTCCGGTAGTAATTTTAGCAAGATTAGCAATAGTAGCAATAGATAGTTCTTATCAAAGTCAAGGTTTAGGACGGGCTTT
ATTTCGTGATGCGGCGCTAAGGGTTGTTCAAGCTGCTGATACAATTGGTATTAGAGGAATTATTGTTCATGCTATTTCTG
AAGAAGCTAAGGATTTTTATTTGGCTTTAGGTTTTATTTTGTCTCCTCTTGAACCAATGACGTTGATGATTACTCTTAAT
GATTTACGTGATTCTATTACTTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11024.67 Da        Isoelectric Point: 8.5952

>AT54274 WP_053538439.1 NZ_CP011456:c1544751-1544461 [Anabaena sp. WA102]
MTNKTKNITVRNTLNLRIKPEERDLIDMAAKVLGKNRTDFILAAARNAAEETLLERTIFWASPEAYAEFIALLDAPPQPN
ERLRKTMQTTPPWDKE

Download         Length: 291 bp

>AT54274 NZ_CP011456:c1544751-1544461 [Anabaena sp. WA102]
ATGACCAATAAAACAAAAAATATAACTGTGCGTAACACCTTAAATTTACGCATTAAGCCAGAGGAACGTGATTTGATAGA
TATGGCCGCCAAAGTGTTAGGTAAAAATAGAACTGATTTTATTTTGGCAGCAGCGCGGAATGCTGCGGAGGAAACTTTGC
TGGAACGGACTATTTTTTGGGCTAGTCCAGAGGCTTATGCAGAATTTATCGCCTTACTAGATGCACCACCCCAACCTAAT
GAGCGTTTACGCAAAACCATGCAGACAACTCCACCTTGGGATAAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2LWM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2LWK8

References