Detailed information of TA system TA054272

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 194348..195009
• Replicon: chromosome
• Accession: NZ_CP011454
• Organism: Gemmatimonas phototrophica strain AP64

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GEMMAAP_RS00870
• Protein ID: WP_026849048.1
• Coordinates: 194596..195009 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A143BFI8
• Locus tag: GEMMAAP_RS00865
• Protein ID: WP_026849047.1
• Coordinates: 194348..194599 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GEMMAAP_RS00835	190165..190542	+	378	WP_026849042.1	DUF2384 domain-containing protein	-
GEMMAAP_RS00840	190502..191260	+	759	WP_026849043.1	RES family NAD+ phosphorylase	-
GEMMAAP_RS00845	191990..192247	+	258	WP_026849044.1	hypothetical protein	-
GEMMAAP_RS00850	192313..192537	+	225	WP_026849045.1	amphi-Trp domain-containing protein	-
GEMMAAP_RS00855	192603..193106	-	504	WP_026849046.1	hypothetical protein	-
GEMMAAP_RS00860	193259..193990	+	732	WP_082820951.1	peptidylprolyl isomerase	-
GEMMAAP_RS00865	194348..194599	+	252	WP_026849047.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
GEMMAAP_RS00870	194596..195009	+	414	WP_026849048.1	type II toxin-antitoxin system VapC family toxin	Toxin
GEMMAAP_RS00875	195204..196829	+	1626	WP_158514679.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-132)

Antitoxin

• Antitoxin VapB-like (1-82)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 14466.70 Da
• Isoelectric Point: 5.0719

>T54272 WP_026849048.1 NZ_CP011454:194596-195009 [Gemmatimonas phototrophica]
VIAASRAAVIDTSALAAIALGEPAADQLVGAVELLAFRLVSAGSILELSLVLQARFGTAADITVDELVRDLHLDVVPFDG
PQLVLARDGARRFGKGRHAASLNFGDLYAYALAMDRQLPLLYVGNHFARTDVLTLAV

Nucleotide

• Length: 414 bp

>T54272 NZ_CP011454:194596-195009 [Gemmatimonas phototrophica]
GTGATCGCCGCATCGCGCGCAGCGGTCATCGACACATCGGCGCTGGCCGCAATCGCACTTGGCGAGCCTGCAGCCGATCA
GCTGGTCGGCGCCGTGGAATTGCTCGCGTTCCGCCTCGTCTCCGCCGGTTCAATTCTCGAACTGTCGCTGGTGCTGCAGG
CCCGCTTCGGCACGGCGGCGGACATAACGGTCGACGAGCTCGTGCGGGATCTGCACCTCGACGTGGTGCCGTTCGACGGT
CCGCAGCTGGTGCTGGCGCGCGATGGCGCCCGGCGCTTTGGTAAAGGCCGGCACGCCGCGTCGCTCAACTTCGGGGACCT
CTACGCCTACGCATTGGCCATGGATCGGCAACTGCCATTGCTGTATGTCGGCAATCATTTCGCGCGCACCGACGTGCTGA
CGCTCGCAGTATAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9329.63 Da
• Isoelectric Point: 5.7378

>AT54272 WP_026849047.1 NZ_CP011454:194348-194599 [Gemmatimonas phototrophica]
MAISIKDPDTDRLARELAAVTGESLTEAIRAALVERLERHQRPERRYPMREAALRIRERLNALPVVNAGAGIELEYDEHG
LPA

Nucleotide

• Length: 252 bp

>AT54272 NZ_CP011454:194348-194599 [Gemmatimonas phototrophica]
ATGGCCATCAGTATCAAGGATCCAGACACCGACCGTCTCGCCCGTGAGCTCGCGGCCGTGACCGGAGAGTCGCTCACCGA
GGCGATCCGTGCCGCGCTGGTCGAGCGACTCGAGCGTCACCAGCGTCCCGAGCGTCGCTATCCCATGCGTGAGGCCGCCC
TTCGCATCCGTGAGCGGCTGAACGCGTTACCGGTAGTGAATGCCGGGGCCGGCATCGAGCTCGAGTACGACGAGCACGGT
CTCCCCGCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A143BFI8