Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4055911..4057469 Replicon chromosome
Accession NZ_CP011427
Organism Pantoea vagans strain ND02

Toxin (Protein)


Gene name hipA Uniprot ID A0A0B1R8F9
Locus tag LK04_RS18735 Protein ID WP_039331996.1
Coordinates 4055911..4057221 (-) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0B1R352
Locus tag LK04_RS18740 Protein ID WP_039331998.1
Coordinates 4057221..4057469 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK04_RS18715 4052172..4052921 - 750 WP_039331992.1 4'-phosphopantetheinyl transferase -
LK04_RS18720 4053213..4053725 + 513 WP_039331993.1 flavin reductase family protein -
LK04_RS18725 4053707..4054780 - 1074 WP_197063327.1 chemotaxis protein -
LK04_RS18730 4055170..4055760 - 591 WP_039331995.1 malonic semialdehyde reductase -
LK04_RS18735 4055911..4057221 - 1311 WP_039331996.1 type II toxin-antitoxin system HipA family toxin Toxin
LK04_RS18740 4057221..4057469 - 249 WP_039331998.1 helix-turn-helix domain-containing protein Antitoxin
LK04_RS18745 4057630..4059000 - 1371 WP_039332000.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
LK04_RS18750 4059084..4060730 - 1647 WP_039332001.1 membrane protein insertase YidC -
LK04_RS20225 4060733..4060990 - 258 WP_007893564.1 membrane protein insertion efficiency factor YidD -
LK04_RS18755 4060954..4061313 - 360 WP_034830013.1 ribonuclease P protein component -
LK04_RS20230 4061328..4061468 - 141 WP_000831330.1 50S ribosomal protein L34 -
LK04_RS20810 4061661..4061837 - 177 WP_167347684.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 49167.23 Da        Isoelectric Point: 6.0193

>T54249 WP_039331996.1 NZ_CP011427:c4057221-4055911 [Pantoea vagans]
MAELDVYMNGYRVGIFTRDSTGSHRFRYVDEWLSQPGSRPISLSMPLRHQPYIGDEVYNFFDNLLPDNPEIRNRILARYH
ADSTQPFDMLEKVGADTVGAIQLLAHDAPPGNVQSIHYQTLNDTELEKILNGYQTGAPLGMLEEIADFRISLAGAQEKTA
LLRLKDQWCLPQGTTPTTHILKLPIGKIQSHSHTIDLTNSVENEWLCTLVAKEFGLPVPECFVVNVGECKALAVERFDRR
WASDARWIMRLPQEDFCQVLNIPSAGKYESHGGPGIQQIMHFLLSSAEVDQDRYNFMKAQVLFWLLAATDGHAKNFSIFI
EAEGRFRLTPFYDILSVYPVIGAKGLHIRDAKLAMGLKGSHGKKYAIEQIFPRHFLATAKAVGFDKTAMEDILQEMSASI
DEVIERVTYQLPDNFPIEIQTTILDGLKARSARLTL

Download         Length: 1311 bp

>T54249 NZ_CP011427:c4057221-4055911 [Pantoea vagans]
ATGGCCGAATTGGACGTTTATATGAACGGCTATAGAGTGGGTATTTTCACCCGCGATAGCACAGGCTCTCATCGGTTTCG
CTATGTTGATGAATGGCTAAGCCAGCCGGGAAGCCGTCCAATTTCCCTATCGATGCCGCTACGTCATCAGCCCTACATCG
GTGACGAGGTCTACAATTTTTTTGATAATCTCCTGCCCGATAATCCTGAAATTCGCAATCGCATCCTCGCACGTTATCAC
GCGGATTCAACTCAGCCATTTGATATGCTTGAAAAAGTAGGCGCAGATACGGTGGGTGCGATCCAACTGCTCGCTCACGA
TGCACCTCCCGGTAACGTGCAATCGATTCATTATCAAACTTTAAATGATACCGAGCTGGAAAAGATTCTGAATGGCTACC
AGACCGGCGCTCCACTTGGCATGCTTGAAGAAATCGCTGATTTTCGTATTTCACTGGCTGGGGCACAGGAAAAAACGGCG
CTGCTCCGTCTGAAGGATCAGTGGTGCTTACCACAGGGTACAACCCCTACAACTCATATTCTTAAGCTGCCGATTGGTAA
AATCCAGAGCCATTCTCATACCATCGATCTCACTAACAGCGTAGAAAACGAATGGCTTTGCACCCTGGTTGCGAAGGAAT
TTGGTTTGCCTGTACCAGAATGCTTTGTGGTCAATGTGGGCGAATGCAAAGCGCTGGCTGTAGAGCGCTTTGATCGCCGA
TGGGCATCAGATGCGCGTTGGATCATGCGTTTACCTCAAGAGGATTTCTGCCAGGTTCTCAATATTCCCTCCGCTGGCAA
ATATGAAAGTCACGGAGGCCCAGGCATTCAACAAATTATGCATTTCCTGTTGAGCTCCGCAGAGGTTGATCAGGATCGCT
ATAACTTTATGAAAGCACAGGTTCTCTTCTGGCTGCTGGCGGCGACAGATGGACATGCCAAAAACTTTTCTATTTTTATC
GAAGCAGAGGGTCGCTTCCGACTGACGCCCTTTTACGACATTCTCTCGGTCTATCCGGTTATTGGGGCAAAAGGACTGCA
TATCCGCGATGCAAAACTCGCTATGGGGTTGAAAGGTTCTCATGGGAAAAAATATGCAATCGAGCAAATCTTTCCTCGTC
ACTTTCTGGCAACAGCCAAAGCGGTGGGATTCGATAAAACAGCGATGGAAGATATCCTGCAAGAAATGAGTGCCAGTATT
GATGAGGTTATCGAACGTGTGACGTATCAGCTGCCTGATAATTTTCCGATCGAAATTCAAACGACGATCCTGGATGGACT
CAAAGCACGTTCGGCTCGCTTAACGCTATAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9418.74 Da        Isoelectric Point: 9.7672

>AT54249 WP_039331998.1 NZ_CP011427:c4057469-4057221 [Pantoea vagans]
MKVTNAKQLSSYLKDVRQSERLSQEKVASKVGIRQDTVSNFELQPGTTKLETLFRILAALNLELEVKPRGQQQEVSGWKE
EW

Download         Length: 249 bp

>AT54249 NZ_CP011427:c4057469-4057221 [Pantoea vagans]
ATGAAAGTCACGAATGCTAAGCAATTGAGCAGCTACCTTAAGGACGTCAGGCAGTCAGAGCGACTGTCTCAGGAAAAAGT
GGCCAGTAAAGTCGGCATCCGACAAGACACCGTATCCAACTTTGAATTGCAGCCAGGCACAACCAAACTGGAAACACTGT
TTCGTATATTGGCGGCTTTGAACCTTGAGTTGGAAGTAAAACCACGCGGTCAGCAGCAAGAAGTCAGCGGCTGGAAGGAA
GAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B1R8F9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B1R352

References