Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1339547..1341195 Replicon chromosome
Accession NZ_CP011427
Organism Pantoea vagans strain ND02

Toxin (Protein)


Gene name hipA Uniprot ID A0A0B1REV0
Locus tag LK04_RS06190 Protein ID WP_039327842.1
Coordinates 1339879..1341195 (-) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0B1RDL4
Locus tag LK04_RS06185 Protein ID WP_039327840.1
Coordinates 1339547..1339882 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK04_RS06170 1336929..1338044 - 1116 WP_039327834.1 succinylglutamate desuccinylase/aspartoacylase family protein -
LK04_RS06175 1338220..1339017 - 798 WP_039327836.1 ABC transporter substrate-binding protein -
LK04_RS06180 1339084..1339560 - 477 WP_039327838.1 YbaK/prolyl-tRNA synthetase associated domain-containing protein -
LK04_RS06185 1339547..1339882 - 336 WP_039327840.1 helix-turn-helix domain-containing protein Antitoxin
LK04_RS06190 1339879..1341195 - 1317 WP_039327842.1 type II toxin-antitoxin system HipA family toxin Toxin
LK04_RS06195 1341314..1341925 - 612 WP_039327843.1 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE -
LK04_RS06200 1341919..1342695 - 777 WP_039327846.1 imidazole glycerol phosphate synthase subunit HisF -
LK04_RS06205 1342677..1343414 - 738 WP_039327847.1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase -
LK04_RS06210 1343414..1344004 - 591 WP_039327849.1 imidazole glycerol phosphate synthase subunit HisH -
LK04_RS06215 1344004..1345071 - 1068 WP_039327852.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
LK04_RS06220 1345068..1346138 - 1071 WP_039327854.1 histidinol-phosphate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gnd / gtrB 1328095..1354495 26400


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(165-355)

Antitoxin

Cro/C1-type helix-turn-helix domain

(29-75)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49475.06 Da        Isoelectric Point: 5.2036

>T54243 WP_039327842.1 NZ_CP011427:c1341195-1339879 [Pantoea vagans]
MLTLQLYLDGQWHDAAELDVKEPSKGRESATLLAYDFNYAAEQLDRNDIASCSLNYPVMLIGSHFAQPWFSFLDDIVPAG
ASRRYWIQHLGLQGKSSAEQDYALLKAGTIAPVGNLRIKDSLPQLPENSQLKTRRFPAEWAIERDSDFLEYAQQMGAASG
GATGAGGEAPKLLLRRNTKSEVWIDTWQDDQQNQDTPYLVKYPRGTRSPIDCDILRAEYHFYHELQAMGIDTIDTQAMLL
CEGERYPSLWLPRFDIAFVENRKVMYGLESIYSLIKKSPGSYLNHFEVIRCLVDRLALTGEHREKLVSEWVKRDMLNIAF
GNSDNHGRNSAILKKSAGMWLAPVYDFAPMKADPEGVVRTTQWGSPYEEGGHYNWQLIAHQLDDLIPEATLLKSLGELAN
KLTGLKGRLADRGVPQSILEMPGIGFNYLDERIAGWQL

Download         Length: 1317 bp

>T54243 NZ_CP011427:c1341195-1339879 [Pantoea vagans]
ATGCTTACCCTACAGCTTTACCTTGATGGACAATGGCACGACGCTGCCGAGCTTGATGTTAAAGAGCCGTCTAAGGGGCG
TGAAAGCGCCACATTGCTTGCCTATGACTTCAATTATGCAGCCGAGCAACTCGACCGAAACGATATCGCAAGCTGCAGCC
TGAACTACCCCGTCATGCTAATTGGCAGCCATTTTGCGCAGCCCTGGTTTAGCTTCCTTGATGATATTGTTCCTGCGGGT
GCAAGCAGACGTTACTGGATTCAACATCTTGGATTACAGGGAAAATCGTCGGCTGAGCAAGATTACGCACTGTTAAAAGC
CGGAACTATTGCGCCTGTTGGAAATTTGCGTATCAAAGATTCCCTTCCCCAATTGCCAGAAAATAGCCAACTCAAAACTC
GACGTTTTCCTGCCGAATGGGCGATTGAGAGAGACAGTGATTTTCTTGAATATGCACAACAAATGGGCGCTGCCAGCGGC
GGCGCAACAGGTGCTGGTGGGGAAGCGCCAAAACTACTTTTAAGGCGAAATACGAAAAGCGAAGTATGGATTGATACTTG
GCAAGACGATCAACAAAACCAGGATACCCCGTATCTGGTCAAGTATCCGCGTGGTACACGCAGCCCAATCGACTGTGACA
TTCTGCGTGCGGAATATCATTTCTATCATGAGTTACAGGCCATGGGCATCGACACGATTGATACCCAGGCAATGCTGTTG
TGCGAAGGTGAAAGATACCCTTCTCTTTGGCTACCACGATTCGATATCGCGTTTGTTGAAAATAGAAAAGTGATGTACGG
GCTGGAATCCATCTATTCGCTGATCAAAAAATCGCCGGGGAGTTATCTCAATCATTTTGAGGTCATTCGATGCCTGGTTG
ATCGATTAGCGCTGACTGGAGAACATCGAGAAAAGTTGGTCAGTGAATGGGTTAAACGCGACATGCTCAATATTGCATTT
GGTAATTCAGATAATCATGGGCGTAACAGTGCCATTCTCAAGAAATCGGCAGGAATGTGGCTTGCACCGGTTTATGACTT
TGCCCCGATGAAAGCCGATCCTGAGGGCGTGGTGCGCACCACTCAGTGGGGCTCACCTTATGAAGAGGGTGGCCACTACA
ATTGGCAATTGATTGCACATCAACTGGACGATCTCATTCCTGAAGCAACACTATTGAAAAGCTTAGGTGAGTTAGCCAAT
AAACTTACTGGATTGAAAGGACGACTTGCCGATCGCGGCGTACCGCAATCTATTCTGGAAATGCCCGGTATTGGCTTTAA
TTATCTGGATGAACGCATTGCTGGGTGGCAGTTATGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12785.95 Da        Isoelectric Point: 10.1441

>AT54243 WP_039327840.1 NZ_CP011427:c1339882-1339547 [Pantoea vagans]
MKKTMTPFEREAMLLDLLQQFIEEKLTHGQLLMQLRKKVLGFSQDRYASLAGISRRTLSDVEQDKESITLTTLNRAFKPL
GLKLGLLPRQTHMMQVLLTNLIQHGESHDHS

Download         Length: 336 bp

>AT54243 NZ_CP011427:c1339882-1339547 [Pantoea vagans]
ATGAAGAAAACGATGACGCCTTTTGAACGAGAAGCCATGTTATTGGACCTTCTACAGCAGTTCATTGAGGAGAAGTTAAC
CCATGGTCAACTCTTAATGCAGCTTCGTAAAAAGGTGCTGGGATTTTCACAGGATCGCTATGCCAGCTTAGCGGGGATCA
GCCGCCGCACTTTATCCGATGTCGAACAGGACAAAGAGAGCATAACGTTGACGACATTGAATCGCGCTTTTAAGCCGCTA
GGATTGAAGCTGGGTTTGTTGCCTCGCCAGACACATATGATGCAGGTACTACTCACCAATCTTATTCAACACGGAGAGTC
TCATGACCACTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B1REV0

Antitoxin

Source ID Structure
AlphaFold DB A0A0B1RDL4

References