Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1513086..1513760 Replicon chromosome
Accession NZ_CP011419
Organism Streptococcus suis strain NSUI002

Toxin (Protein)


Gene name hicA Uniprot ID A0A123U128
Locus tag AA105_RS07640 Protein ID WP_009910449.1
Coordinates 1513578..1513760 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7Y6VEQ2
Locus tag AA105_RS07635 Protein ID WP_009910448.1
Coordinates 1513086..1513538 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA105_RS07605 1509081..1510085 + 1005 WP_009910438.1 lactonase family protein -
AA105_RS07610 1510149..1510334 + 186 WP_002935693.1 hypothetical protein -
AA105_RS07615 1510367..1511008 - 642 WP_002935700.1 HAD family hydrolase -
AA105_RS07620 1511175..1511435 - 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin -
AA105_RS07625 1511437..1511658 - 222 WP_012775256.1 hypothetical protein -
AA105_RS07630 1512765..1512974 - 210 WP_009910447.1 hypothetical protein -
AA105_RS07635 1513086..1513538 - 453 WP_009910448.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AA105_RS07640 1513578..1513760 - 183 WP_009910449.1 type II toxin-antitoxin system HicA family toxin Toxin
AA105_RS07645 1513944..1514330 - 387 WP_009910450.1 hypothetical protein -
AA105_RS07650 1514470..1514970 - 501 WP_024409209.1 hypothetical protein -
AA105_RS07655 1515040..1515480 - 441 WP_024409208.1 hypothetical protein -
AA105_RS07660 1515948..1516793 - 846 WP_024409207.1 ATP-binding protein -
AA105_RS07665 1516809..1517603 - 795 WP_079269917.1 DnaD domain protein -
AA105_RS07670 1517617..1517832 - 216 WP_024409205.1 hypothetical protein -
AA105_RS12120 1517837..1517995 - 159 WP_162841287.1 hypothetical protein -
AA105_RS07675 1518006..1518272 - 267 WP_024409204.1 hypothetical protein -
AA105_RS07680 1518283..1518486 - 204 WP_024409203.1 hypothetical protein -
AA105_RS07685 1518479..1518682 - 204 WP_024409202.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1510367..1536366 25999


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6681.93 Da        Isoelectric Point: 10.8207

>T54239 WP_009910449.1 NZ_CP011419:c1513760-1513578 [Streptococcus suis]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKVGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

>T54239 NZ_CP011419:c1513760-1513578 [Streptococcus suis]
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCCCATGGTTGGACAAAAACTAAAGGTGGTAAGGGGTCTCA
CGTTAAACTTGAAAAAGTAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATTAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16672.68 Da        Isoelectric Point: 4.0098

>AT54239 WP_009910448.1 NZ_CP011419:c1513538-1513086 [Streptococcus suis]
MLVTYPALFYYDDTDGATAPYFVTFPDFEHSATQGEDMADAMAMASDWLGIHLADYIENGRDIPTPTPINALSLADNNPF
RDDKDIELVYDPSKSFVSMVMVDVAEYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 453 bp

>AT54239 NZ_CP011419:c1513538-1513086 [Streptococcus suis]
ATGCTTGTCACTTATCCAGCTTTATTTTATTATGACGATACAGACGGAGCTACCGCCCCTTATTTTGTCACTTTCCCAGA
CTTTGAACATTCAGCAACTCAGGGCGAAGATATGGCAGACGCTATGGCAATGGCTAGTGATTGGTTAGGTATTCATCTAG
CTGATTATATTGAGAATGGGCGTGATATTCCCACTCCTACCCCTATTAACGCTTTATCATTGGCTGATAATAACCCTTTC
CGTGATGATAAGGACATAGAGCTAGTTTATGACCCTAGCAAGTCTTTTGTATCTATGGTTATGGTTGACGTTGCTGAGTA
TCTAGGCAGTCAAGAGCCTGTAAAGAAAACACTAACTATTCCACGTTGGGCGGATACTTTAGGGCGTGAGTTAGGGCTAA
ATTTCTCACAGACCTTAACAGACGCTATTGCAGATAAGAAAATTCATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A123U128

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y6VEQ2

References