Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1511175..1511658 Replicon chromosome
Accession NZ_CP011419
Organism Streptococcus suis strain NSUI002

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8BIZ7
Locus tag AA105_RS07620 Protein ID WP_009910443.1
Coordinates 1511175..1511435 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag AA105_RS07625 Protein ID WP_012775256.1
Coordinates 1511437..1511658 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA105_RS07595 1506560..1507789 - 1230 WP_009910437.1 tetratricopeptide repeat protein -
AA105_RS07600 1507779..1508945 - 1167 WP_002935690.1 AI-2E family transporter -
AA105_RS07605 1509081..1510085 + 1005 WP_009910438.1 lactonase family protein -
AA105_RS07610 1510149..1510334 + 186 WP_002935693.1 hypothetical protein -
AA105_RS07615 1510367..1511008 - 642 WP_002935700.1 HAD family hydrolase -
AA105_RS07620 1511175..1511435 - 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AA105_RS07625 1511437..1511658 - 222 WP_012775256.1 hypothetical protein Antitoxin
AA105_RS07630 1512765..1512974 - 210 WP_009910447.1 hypothetical protein -
AA105_RS07635 1513086..1513538 - 453 WP_009910448.1 type II toxin-antitoxin system HicB family antitoxin -
AA105_RS07640 1513578..1513760 - 183 WP_009910449.1 type II toxin-antitoxin system HicA family toxin -
AA105_RS07645 1513944..1514330 - 387 WP_009910450.1 hypothetical protein -
AA105_RS07650 1514470..1514970 - 501 WP_024409209.1 hypothetical protein -
AA105_RS07655 1515040..1515480 - 441 WP_024409208.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1510367..1536366 25999


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10270.78 Da        Isoelectric Point: 9.6925

>T54238 WP_009910443.1 NZ_CP011419:c1511435-1511175 [Streptococcus suis]
MYHLEYSKKAQKQIKKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T54238 NZ_CP011419:c1511435-1511175 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTAAGAAATTAGATAGGCAAATTCAGAGGTTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT54238 WP_012775256.1 NZ_CP011419:c1511658-1511437 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT54238 NZ_CP011419:c1511658-1511437 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8BIZ7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References