Detailed information of TA system TA054236

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 1126576..1127846
• Replicon: chromosome
• Accession: NZ_CP011419
• Organism: Streptococcus suis strain NSUI002

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: A0A0Z8INM2
• Locus tag: AA105_RS05775
• Protein ID: WP_024409332.1
• Coordinates: 1126576..1127370 (-)
• Length: 265 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: AA105_RS05780
• Protein ID: WP_024409333.1
• Coordinates: 1127370..1127846 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AA105_RS05755	1121616..1123529	-	1914	WP_053338584.1	ATP-dependent helicase	-
AA105_RS05760	1123526..1125349	-	1824	Protein_1084	AAA family ATPase	-
AA105_RS05765	1125357..1126301	-	945	WP_024409330.1	IS30 family transposase	-
AA105_RS05770	1126392..1126595	-	204	Protein_1086	AAA family ATPase	-
AA105_RS05775	1126576..1127370	-	795	WP_024409332.1	zeta toxin family protein	Toxin
AA105_RS05780	1127370..1127846	-	477	WP_024409333.1	helix-turn-helix domain-containing protein	Antitoxin
AA105_RS05785	1127916..1128200	-	285	WP_024409334.1	hypothetical protein	-
AA105_RS05790	1128244..1128639	-	396	WP_017285409.1	hypothetical protein	-
AA105_RS05795	1128643..1128870	-	228	WP_024409335.1	hypothetical protein	-
AA105_RS05800	1128924..1130012	-	1089	WP_024409336.1	toprim domain-containing protein	-
AA105_RS05805	1130052..1130690	-	639	WP_024409337.1	hypothetical protein	-
AA105_RS05810	1130801..1131091	-	291	WP_024409338.1	hypothetical protein	-
AA105_RS05815	1131106..1131405	-	300	WP_024382151.1	hypothetical protein	-
AA105_RS05820	1131475..1132386	-	912	WP_032505215.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(O)	-	1105623..1174430	68807

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (26-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 265 a.a.
• Molecular weight: 30360.57 Da
• Isoelectric Point: 6.6151

>T54236 WP_024409332.1 NZ_CP011419:c1127370-1126576 [Streptococcus suis]
MRLEEFSKDDFDLALKRTIRSLTRGKTTSVTPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSLHPNYLTLQE
EYGKDSVDYTKGFAGKMVEQLVDELSKQGYHLLIEGTLRTTEVPRKTARLLKARGYQVSLALIATKPELSYLSTLIRYEE
VYVVNPNQARATPKEHHDGIVNHLVDNLRELENDHLFDYIQIYQRDRSCVYDSETDDGSAAEVLQECLFGKWSKVEEEMM
KMGQELLMEFLEMKKGRIYENKKN

Nucleotide

• Length: 795 bp

>T54236 NZ_CP011419:c1127370-1126576 [Streptococcus suis]
ATGCGGTTAGAAGAATTTAGCAAAGATGACTTTGACTTAGCCTTAAAACGAACTATTCGTTCCTTAACTCGTGGTAAAAC
GACATCAGTTACCCCAAAAGCCATCTTACTTGGTGGGCAAAGTGGAGCAGGAAAAACAACGATACACCGTATCAAGCAGA
AAGAGTTCCAAGGTAATATTATCATTATTGACGGTGATAGCTACCGCTCTTTACACCCGAATTATCTAACTTTACAAGAA
GAGTACGGGAAGGATAGCGTGGATTATACCAAAGGTTTTGCAGGAAAAATGGTGGAACAGCTTGTGGATGAACTCAGTAA
ACAAGGTTATCATTTGTTAATCGAAGGAACTTTGAGAACGACAGAAGTCCCACGAAAAACAGCACGGCTATTGAAAGCGA
GAGGTTATCAAGTCTCATTAGCTTTGATAGCAACCAAGCCTGAATTGTCTTATCTCAGCACCTTAATCCGCTACGAAGAA
GTCTATGTGGTTAATCCAAACCAAGCTAGAGCAACTCCTAAAGAACATCATGATGGAATTGTCAATCACTTGGTTGATAA
CTTACGAGAGCTAGAAAACGACCATCTCTTTGATTATATTCAAATTTATCAAAGAGATAGAAGTTGTGTTTATGATTCGG
AAACTGATGACGGTTCAGCAGCAGAAGTGCTACAAGAATGCCTCTTCGGAAAATGGAGCAAGGTGGAGGAAGAGATGATG
AAGATGGGACAGGAATTGTTGATGGAGTTTTTGGAAATGAAAAAAGGTAGAATTTATGAAAATAAAAAAAATTAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18119.46 Da
• Isoelectric Point: 4.3193

>AT54236 WP_024409333.1 NZ_CP011419:c1127846-1127370 [Streptococcus suis]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSLSTELIDRICQKFNVSYVDIVGEEKMLTPVEDYQLTLKIE
VIKERGAAILSELYRYQDSQGITFDDETSPWILMSDDLSDLINTKIYLVNTFDEVERYNGYLDGIERMLELANHQVVA

Nucleotide

• Length: 477 bp

>AT54236 NZ_CP011419:c1127846-1127370 [Streptococcus suis]
ATGATTGGAGATAATATTAAATCGTTACGTAAAACCCATGATTTAACACAACCAGAATTCGCAAAGATTGTTGGAATTTC
TCGAAATAGTTTGAGCCGTTATGAAAATGGGACAAGCTCGTTATCAACAGAGCTCATAGACCGTATCTGTCAGAAATTTA
ATGTATCATATGTTGATATTGTAGGAGAAGAAAAAATGTTAACACCAGTGGAAGATTATCAATTAACCTTAAAAATTGAA
GTTATCAAAGAGCGTGGCGCAGCGATTTTGTCCGAACTATATCGCTATCAAGATAGTCAAGGAATTACTTTTGATGATGA
GACTAGCCCTTGGATTTTGATGAGTGATGATTTGTCTGATCTTATCAATACCAAGATTTACCTTGTCAATACTTTTGATG
AAGTGGAGCGTTACAATGGTTATTTAGATGGTATTGAGCGAATGTTGGAGCTTGCTAATCATCAGGTGGTGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Z8INM2