Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1042204..1042690 Replicon chromosome
Accession NZ_CP011419
Organism Streptococcus suis strain NSUI002

Toxin (Protein)


Gene name relE Uniprot ID A0A0K2E5U8
Locus tag AA105_RS05385 Protein ID WP_002935012.1
Coordinates 1042204..1042461 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0K2E5B0
Locus tag AA105_RS05390 Protein ID WP_002935014.1
Coordinates 1042451..1042690 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA105_RS05365 1037838..1038908 + 1071 WP_002935006.1 tyrosine recombinase XerS -
AA105_RS05370 1038978..1040486 - 1509 WP_013730362.1 phosphoglucomutase -
AA105_RS05375 1040562..1041503 - 942 WP_002935009.1 sensor histidine kinase -
AA105_RS05380 1041500..1042165 - 666 WP_009909826.1 response regulator transcription factor -
AA105_RS05385 1042204..1042461 - 258 WP_002935012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AA105_RS05390 1042451..1042690 - 240 WP_002935014.1 hypothetical protein Antitoxin
AA105_RS05395 1042782..1044752 - 1971 WP_013730363.1 FtsX-like permease family protein -
AA105_RS05400 1044753..1045505 - 753 WP_002935019.1 ABC transporter ATP-binding protein -
AA105_RS05405 1045522..1045905 - 384 WP_002935021.1 NisI/SpaI family lantibiotic immunity lipoprotein -
AA105_RS12095 1045918..1046058 - 141 WP_002935023.1 hypothetical protein -
AA105_RS05415 1046157..1046891 - 735 WP_002935025.1 beta-carotene 15,15'-monooxygenase -
AA105_RS12100 1046904..1047041 - 138 WP_002935027.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-75)

Antitoxin

Protein of unknown function DUF6290

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9849.52 Da        Isoelectric Point: 10.7134

>T54235 WP_002935012.1 NZ_CP011419:c1042461-1042204 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T54235 NZ_CP011419:c1042461-1042204 [Streptococcus suis]
TTGAGTTATAAGGTTATTTTGTCTGCTAAGGCCCAAAAGCAAATTCGAAAGATGGATAAAACCGCTGCAAGTTTGATTTT
GCGCTATCTCTACAAGCATATTGACGGTTGCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8924.19 Da        Isoelectric Point: 3.9191

>AT54235 WP_002935014.1 NZ_CP011419:c1042690-1042451 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPMTLEQMAEELGIEL

Download         Length: 240 bp

>AT54235 NZ_CP011419:c1042690-1042451 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGACGAGTACGATGCGCGTGTGGCAGACGTTGCTTGGGCAG
AATACCAAGCAGACTTGGCGAATAGAATTGAGCCGATGACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E5U8

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E5B0

References