Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
| Location | 41750..42309 | Replicon | plasmid pCFSAN029787_01 |
| Accession | NZ_CP011417 | ||
| Organism | Escherichia coli strain CFSAN029787 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D2AJT2 |
| Locus tag | AA102_RS25245 | Protein ID | WP_000421262.1 |
| Coordinates | 42034..42309 (+) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A0M1UJH5 |
| Locus tag | AA102_RS25240 | Protein ID | WP_038341659.1 |
| Coordinates | 41750..42034 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AA102_RS30825 | 38516..38785 | - | 270 | Protein_43 | transposase | - |
| AA102_RS31560 | 38900..39538 | - | 639 | WP_000607008.1 | type III secretion system effector OspI | - |
| AA102_RS30180 | 39697..40167 | - | 471 | Protein_45 | IS1 family transposase | - |
| AA102_RS25225 | 40503..40688 | + | 186 | Protein_46 | ATP-binding protein | - |
| AA102_RS27275 | 40788..40997 | - | 210 | Protein_47 | peptidoglycan-binding protein | - |
| AA102_RS25235 | 41047..41226 | - | 180 | Protein_48 | MFS transporter | - |
| AA102_RS25240 | 41750..42034 | + | 285 | WP_038341659.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| AA102_RS25245 | 42034..42309 | + | 276 | WP_000421262.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AA102_RS31885 | 42441..42578 | - | 138 | WP_000766699.1 | hypothetical protein | - |
| AA102_RS28960 | 42685..43036 | - | 352 | Protein_52 | plasmid partitioning/stability family protein | - |
| AA102_RS25255 | 43039..43607 | - | 569 | Protein_53 | plasmid segregation protein ParM | - |
| AA102_RS30185 | 43615..44706 | + | 1092 | Protein_54 | IS66 family transposase | - |
| AA102_RS28970 | 44901..46109 | - | 1209 | WP_000198523.1 | IS91 family transposase | - |
| AA102_RS25280 | 46090..46362 | - | 273 | WP_000019158.1 | hypothetical protein | - |
| AA102_RS25285 | 46522..46740 | + | 219 | WP_000813626.1 | type II toxin-antitoxin system antitoxin CcdA | - |
| AA102_RS25290 | 46742..47047 | + | 306 | WP_001159860.1 | type II toxin-antitoxin system toxin CcdB | - |
| AA102_RS30840 | 47083..47178 | + | 96 | Protein_59 | transposase domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | mxiD / mxiC / mxiA / spa15 / spa47 / spa13 / spa32 / spa33 / spa24 / spa9 / spa29 / spa40 / virA / icsA/virG / papC / ospI / ipaH9.8 / ospG / ospC2 / nleE / icsP/sopA / ospB / ospC4 / ospC4 / ospC2 / ospD2 / ospF / ospD1 / ipgB2 / ipaH4.5 / ipaH7.8 / ipaH1.4 / ospE1 / ospE2 / senB / faeC / faeD / faeE / faeF / faeH / faeI / ospC1 / ospD3/senA / ospD3/senA / ospC3 / ipaJ / ipaA / ipaD / ipaC / ipaB / ipgC / ipgB1 / ipgA / icsB / ipgD / ipgE / ipgF / mxiG / mxiH / mxiI / mxiJ / mxiK / mxiN / mxiL / mxiM / mxiE | 1..293826 | 293826 | |
| - | inside | IScluster/Tn | - | ospI / ipaH9.8 / ospG | 28333..52660 | 24327 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10766.48 Da Isoelectric Point: 9.9324
>T54224 WP_000421262.1 NZ_CP011417:42034-42309 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFTGEYEIRYELTGQTIY
VLRLWHTRENR
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFTGEYEIRYELTGQTIY
VLRLWHTRENR
Download Length: 276 bp
>T54224 NZ_CP011417:42034-42309 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTACTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAGAACAGGTAG
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTACTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAGAACAGGTAG
Antitoxin
Download Length: 95 a.a. Molecular weight: 10444.88 Da Isoelectric Point: 5.5648
>AT54224 WP_038341659.1 NZ_CP011417:41750-42034 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEECNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDHPLPVPR
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEECNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDHPLPVPR
Download Length: 285 bp
>AT54224 NZ_CP011417:41750-42034 [Escherichia coli]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAAGAGGAGG
AGTGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACCATCCGTTACCGGTGCCACGCTGA
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAAGAGGAGG
AGTGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACCATCCGTTACCGGTGCCACGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A822PVM3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0M1UJH5 |