Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1242479..1243133 Replicon chromosome
Accession NZ_CP011416
Organism Escherichia coli strain CFSAN029787

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag AA102_RS06410 Protein ID WP_024206778.1
Coordinates 1242479..1242886 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag AA102_RS06415 Protein ID WP_000354046.1
Coordinates 1242867..1243133 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA102_RS06390 1238436..1240169 - 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -
AA102_RS06395 1240175..1240885 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AA102_RS06400 1240910..1241806 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
AA102_RS06405 1241918..1242439 + 522 WP_001055870.1 flavodoxin FldB -
AA102_RS06410 1242479..1242886 - 408 WP_024206778.1 protein YgfX Toxin
AA102_RS06415 1242867..1243133 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
AA102_RS06420 1243376..1244356 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
AA102_RS06425 1244552..1245211 - 660 WP_000250274.1 hemolysin III family protein -
AA102_RS06430 1245375..1245686 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
AA102_RS06435 1245731..1247164 + 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
AA102_RS06440 1247221..1247964 - 744 WP_000951948.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16017.93 Da        Isoelectric Point: 11.5202

>T54205 WP_024206778.1 NZ_CP011416:c1242886-1242479 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRVLLQQETQR

Download         Length: 408 bp

>T54205 NZ_CP011416:c1242886-1242479 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGGTTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT54205 WP_000354046.1 NZ_CP011416:c1243133-1242867 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT54205 NZ_CP011416:c1243133-1242867 [Escherichia coli]
ATGGACATTAATAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References