Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1580987..1581599 Replicon chromosome
Accession NZ_CP011415
Organism Streptococcus pyogenes strain D471

Toxin (Protein)


Gene name parE Uniprot ID Q5X9X8
Locus tag SpyM6D471_RS07940 Protein ID WP_011018227.1
Coordinates 1581264..1581599 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag SpyM6D471_RS07935 Protein ID WP_002988079.1
Coordinates 1580987..1581274 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SpyM6D471_RS07910 1576178..1577161 - 984 WP_011184964.1 tagatose-bisphosphate aldolase -
SpyM6D471_RS07915 1577165..1578094 - 930 WP_011184965.1 tagatose-6-phosphate kinase -
SpyM6D471_RS07920 1578140..1578655 - 516 WP_011184966.1 galactose-6-phosphate isomerase subunit LacB -
SpyM6D471_RS07925 1578690..1579118 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
SpyM6D471_RS07930 1579564..1580337 + 774 WP_011184967.1 DeoR/GlpR family DNA-binding transcription regulator -
SpyM6D471_RS07935 1580987..1581274 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
SpyM6D471_RS07940 1581264..1581599 + 336 WP_011018227.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SpyM6D471_RS09690 1581697..1582735 + 1039 Protein_1513 site-specific integrase -
SpyM6D471_RS07950 1582867..1583259 - 393 WP_002982716.1 30S ribosomal protein S9 -
SpyM6D471_RS07955 1583280..1583726 - 447 WP_011018228.1 50S ribosomal protein L13 -
SpyM6D471_RS07960 1583944..1584150 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
SpyM6D471_RS07965 1584147..1584845 - 699 WP_021340263.1 hypothetical protein -
SpyM6D471_RS07970 1584981..1585841 - 861 WP_002982687.1 DegV family protein -
SpyM6D471_RS07975 1585938..1586456 - 519 WP_011055010.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13171.97 Da        Isoelectric Point: 5.2144

>T54202 WP_011018227.1 NZ_CP011415:1581264-1581599 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T54202 NZ_CP011415:1581264-1581599 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT54202 WP_002988079.1 NZ_CP011415:1580987-1581274 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT54202 NZ_CP011415:1580987-1581274 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAACAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z2QKE7

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References