Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 15791..17478 Replicon chromosome
Accession NZ_CP011409
Organism Herbaspirillum hiltneri N3

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag F506_RS00070 Protein ID WP_016836215.1
Coordinates 16135..17478 (+) Length 448 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag F506_RS22455 Protein ID WP_083458183.1
Coordinates 15791..16132 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F506_RS00035 10999..11625 - 627 WP_053194683.1 ATP-binding cassette domain-containing protein -
F506_RS00040 11703..12218 - 516 WP_053194684.1 DUF421 domain-containing protein -
F506_RS00045 12487..13425 + 939 WP_053194685.1 LysR family transcriptional regulator -
F506_RS00050 13485..14405 + 921 WP_053194686.1 ornithine cyclodeaminase family protein -
F506_RS00055 14688..15449 + 762 WP_053194687.1 SDR family oxidoreductase -
F506_RS00060 15486..15680 + 195 WP_016836213.1 hypothetical protein -
F506_RS22455 15791..16132 + 342 WP_083458183.1 helix-turn-helix domain-containing protein Antitoxin
F506_RS00070 16135..17478 + 1344 WP_016836215.1 type II toxin-antitoxin system HipA family toxin Toxin
F506_RS00075 17480..17797 - 318 WP_053194688.1 ferredoxin family protein -
F506_RS00080 17837..18202 - 366 WP_053194689.1 hypothetical protein -
F506_RS00085 18286..18870 - 585 WP_053201085.1 sigma-70 family RNA polymerase sigma factor -
F506_RS00090 19180..20265 + 1086 WP_144423961.1 sensor domain-containing diguanylate cyclase -
F506_RS00095 20279..22132 - 1854 WP_053194690.1 peptide transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-67)


Sequences

Toxin        


Download         Length: 448 a.a.        Molecular weight: 49403.15 Da        Isoelectric Point: 6.2878

>T54195 WP_016836215.1 NZ_CP011409:16135-17478 [Herbaspirillum hiltneri N3]
MGRRTLTQRLFVWMNGIRVAAWDKTRDEERLSYFPEWQEQEEGRPLSLSLPFTPNNLVYRGALVSSFFDNLLPDNDAIRR
RLAQRYHAENTDPFSLLAELGRDCVGAIQLLPPDVAPTDLFSISGRPLDEAEVANLLRNTTSAAILGQTGEHDDLRLSIA
GAQEKTALLYHEGAWHLPQGSTPTTHIFKLPLGLVGNRRADMQSSVENEWLCSKLMAAYELPIAHCDIGRFEDQKVLIVE
RFDRKPASDGSWIIRLPQEDMCQATGTPSLRKYQADGGPGIADVIHVLDRSDKAQQDKRNFFKTQIVFWLLAATDGHAKN
FSIAHLPGGSYCATPLYDVLSAHPITGPGPNQMAAQRLKLAMAVRSTSNYYLIDRIQRRHWGAQAAQVGLGAAAAEEIIE
EVIAATDGVLDAVGRQLPEDFPAKLADVIFSGVARQCKRLAAMPAGV

Download         Length: 1344 bp

>T54195 NZ_CP011409:16135-17478 [Herbaspirillum hiltneri N3]
ATGGGTCGCCGTACGCTGACGCAACGACTCTTCGTCTGGATGAATGGCATTCGCGTGGCTGCCTGGGACAAGACCCGGGA
CGAGGAACGCCTGAGCTATTTCCCAGAGTGGCAGGAGCAGGAGGAAGGACGGCCCCTGTCGCTCTCGCTGCCGTTCACGC
CAAATAACTTGGTCTACCGCGGCGCGCTTGTTTCTTCCTTCTTCGACAATCTCTTGCCGGACAACGATGCGATTCGCCGT
CGTCTGGCGCAGCGTTATCACGCAGAAAATACCGATCCATTTTCTTTGCTGGCAGAACTCGGCCGCGATTGTGTCGGCGC
CATTCAGCTCTTGCCCCCGGACGTAGCGCCGACGGATTTGTTTTCCATTTCCGGCAGACCTCTGGACGAGGCGGAAGTCG
CGAATCTCCTGCGCAACACCACGAGCGCCGCGATTCTCGGACAGACCGGCGAGCACGACGATCTGCGCCTGTCCATCGCT
GGCGCGCAGGAAAAGACTGCGCTGCTTTATCACGAGGGCGCATGGCATTTGCCGCAAGGGAGTACGCCGACCACACACAT
CTTCAAACTGCCGCTGGGACTGGTCGGCAACCGGCGCGCCGACATGCAGAGCTCGGTCGAGAACGAATGGCTGTGTTCAA
AACTGATGGCCGCATATGAATTGCCGATCGCTCATTGCGACATCGGCCGTTTCGAAGATCAGAAGGTGCTGATCGTCGAG
CGTTTTGATCGCAAGCCGGCGAGTGATGGCAGCTGGATCATTCGCCTGCCGCAGGAAGACATGTGCCAGGCAACGGGAAC
GCCGTCCCTGCGCAAATATCAGGCGGATGGCGGCCCCGGCATTGCCGACGTCATCCATGTGCTTGACAGGTCGGATAAGG
CGCAGCAGGACAAGCGCAATTTTTTCAAGACGCAGATCGTGTTCTGGTTGCTGGCGGCGACCGACGGCCATGCCAAGAAT
TTCAGCATCGCCCATCTGCCCGGGGGGAGTTATTGCGCCACGCCTTTGTACGATGTTTTGTCGGCGCATCCGATCACCGG
TCCGGGGCCGAACCAGATGGCGGCACAGCGTCTGAAGCTGGCGATGGCTGTGCGCAGCACCAGCAACTACTATCTGATCG
ACAGAATCCAGCGCCGCCATTGGGGCGCGCAAGCAGCCCAGGTGGGACTCGGCGCTGCGGCGGCCGAAGAGATCATTGAA
GAAGTCATCGCGGCGACTGACGGCGTGCTTGATGCAGTCGGCAGGCAATTGCCAGAAGATTTTCCTGCCAAGCTGGCGGA
CGTAATCTTCAGCGGCGTCGCCCGTCAGTGCAAGCGACTCGCCGCCATGCCTGCAGGCGTCTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12377.46 Da        Isoelectric Point: 11.0197

>AT54195 WP_083458183.1 NZ_CP011409:15791-16132 [Herbaspirillum hiltneri N3]
MLYPIKTLSQLRPILQGFRKEAGLTQAALAERLGMSQQNYAKLEANPASVSMERLHAVFSVLNVEMALSQAGTAVTVTTS
PAVPTRKPTLKTTTKEPQSLRRVTSPAIKKEVW

Download         Length: 342 bp

>AT54195 NZ_CP011409:15791-16132 [Herbaspirillum hiltneri N3]
ATGCTCTATCCCATCAAAACCCTCAGTCAGCTTCGGCCGATCCTGCAAGGCTTTCGCAAGGAAGCAGGACTGACCCAAGC
GGCGCTGGCGGAGCGCTTGGGCATGTCCCAGCAGAATTATGCCAAGCTCGAAGCCAATCCGGCCTCGGTCAGCATGGAGC
GTCTTCACGCTGTATTCAGCGTACTGAACGTGGAGATGGCGTTAAGCCAGGCAGGAACTGCCGTCACGGTAACCACTTCG
CCCGCAGTGCCAACGCGCAAACCTACACTCAAGACAACAACAAAAGAGCCGCAATCCCTGCGCCGCGTCACTTCGCCAGC
CATTAAAAAAGAGGTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References