Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE(toxin) |
| Location | 2117024..2117583 | Replicon | chromosome |
| Accession | NZ_CP011406 | ||
| Organism | Vibrio parahaemolyticus strain FORC_014 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A249W5L8 |
| Locus tag | FORC14_RS09865 | Protein ID | WP_005497247.1 |
| Coordinates | 2117305..2117583 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | FORC14_RS09860 | Protein ID | WP_063517581.1 |
| Coordinates | 2117024..2117308 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC14_RS09825 | 2112567..2113034 | - | 468 | WP_140288196.1 | hypothetical protein | - |
| FORC14_RS25065 | 2113061..2113153 | - | 93 | WP_079390553.1 | DUF3265 domain-containing protein | - |
| FORC14_RS09830 | 2113176..2114054 | - | 879 | WP_063517577.1 | hypothetical protein | - |
| FORC14_RS09840 | 2114709..2115002 | - | 294 | WP_063517578.1 | hypothetical protein | - |
| FORC14_RS25070 | 2115029..2115148 | - | 120 | WP_079771492.1 | DUF3265 domain-containing protein | - |
| FORC14_RS09845 | 2115135..2115509 | - | 375 | WP_063517579.1 | hypothetical protein | - |
| FORC14_RS25075 | 2115543..2115632 | - | 90 | WP_074531745.1 | DUF3265 domain-containing protein | - |
| FORC14_RS09850 | 2115664..2116032 | - | 369 | WP_017449638.1 | VOC family protein | - |
| FORC14_RS09855 | 2116170..2116856 | - | 687 | WP_063517580.1 | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | - |
| FORC14_RS09860 | 2117024..2117308 | + | 285 | WP_063517581.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| FORC14_RS09865 | 2117305..2117583 | + | 279 | WP_005497247.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| FORC14_RS09870 | 2117720..2118229 | - | 510 | WP_063517582.1 | ClbS/DfsB family four-helix bundle protein | - |
| FORC14_RS09875 | 2118365..2118961 | - | 597 | WP_063517583.1 | methyltransferase domain-containing protein | - |
| FORC14_RS25080 | 2118999..2119076 | - | 78 | WP_079771542.1 | DUF3265 domain-containing protein | - |
| FORC14_RS09880 | 2119116..2119577 | - | 462 | WP_063517584.1 | hypothetical protein | - |
| FORC14_RS09885 | 2119591..2119866 | - | 276 | WP_063517585.1 | hypothetical protein | - |
| FORC14_RS25085 | 2119894..2120013 | - | 120 | WP_079771494.1 | DUF3265 domain-containing protein | - |
| FORC14_RS09890 | 2120000..2120374 | - | 375 | WP_063517586.1 | hypothetical protein | - |
| FORC14_RS25090 | 2120957..2121073 | - | 117 | WP_074531696.1 | DUF3265 domain-containing protein | - |
| FORC14_RS09895 | 2121052..2121495 | - | 444 | WP_063517587.1 | NUDIX domain-containing protein | - |
| FORC14_RS25095 | 2121524..2121616 | - | 93 | Protein_1964 | DUF3265 domain-containing protein | - |
| FORC14_RS09900 | 2121631..2121984 | - | 354 | WP_063517588.1 | hypothetical protein | - |
| FORC14_RS25100 | 2122013..2122105 | - | 93 | WP_079771495.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2049328..2140163 | 90835 | |
| - | inside | Integron | - | - | 2050242..2138452 | 88210 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10914.61 Da Isoelectric Point: 4.4755
>T54194 WP_005497247.1 NZ_CP011406:2117305-2117583 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPEAAEKTDEVIEAKVENLLEQPHMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRIM
RVLHQKQKFPVS
MILWEEESLNDREKIFEFLYDFNPEAAEKTDEVIEAKVENLLEQPHMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRIM
RVLHQKQKFPVS
Download Length: 279 bp
>T54194 NZ_CP011406:2117305-2117583 [Vibrio parahaemolyticus]
ATGATTTTGTGGGAAGAAGAGTCTCTCAACGATCGTGAAAAGATCTTTGAGTTTCTTTACGACTTCAACCCAGAGGCTGC
TGAAAAAACCGATGAAGTTATTGAAGCCAAAGTGGAGAACCTTCTAGAACAACCTCATATGGGAGTCCAACGAGACGGAA
TTAGAGGGCGATTGCTCATTATTCCAGAGATATCAATGATTGTTTCGTACTGGGTTGAAGGCGATATCATTCGCATTATG
CGTGTACTACACCAAAAACAAAAATTCCCTGTGAGCTAG
ATGATTTTGTGGGAAGAAGAGTCTCTCAACGATCGTGAAAAGATCTTTGAGTTTCTTTACGACTTCAACCCAGAGGCTGC
TGAAAAAACCGATGAAGTTATTGAAGCCAAAGTGGAGAACCTTCTAGAACAACCTCATATGGGAGTCCAACGAGACGGAA
TTAGAGGGCGATTGCTCATTATTCCAGAGATATCAATGATTGTTTCGTACTGGGTTGAAGGCGATATCATTCGCATTATG
CGTGTACTACACCAAAAACAAAAATTCCCTGTGAGCTAG
Antitoxin
Download Length: 95 a.a. Molecular weight: 10895.22 Da Isoelectric Point: 9.1865
>AT54194 WP_063517581.1 NZ_CP011406:2117024-2117308 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLADQQRKTLSHDAWLTEQVNLAFEKFDSGKATFVDHESAKSR
IAERKAKIRNRGKL
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLADQQRKTLSHDAWLTEQVNLAFEKFDSGKATFVDHESAKSR
IAERKAKIRNRGKL
Download Length: 285 bp
>AT54194 NZ_CP011406:2117024-2117308 [Vibrio parahaemolyticus]
ATGGACACCAGAATTCAGTTTCGTGTTGATGAAGAAACGAAACGACTAGCCCAGCAAATGGCAGAAAGCCAAGGCAGAAC
ACTAAGTGACGCTTGTCGTGAACTGACTGAACAACTAGCTGACCAACAGAGAAAGACTTTATCTCACGATGCATGGTTAA
CTGAACAAGTTAACTTGGCTTTTGAGAAGTTTGACTCAGGAAAAGCCACTTTTGTTGATCACGAATCAGCTAAATCACGT
ATTGCTGAGCGCAAAGCTAAAATCCGTAACCGAGGCAAATTATGA
ATGGACACCAGAATTCAGTTTCGTGTTGATGAAGAAACGAAACGACTAGCCCAGCAAATGGCAGAAAGCCAAGGCAGAAC
ACTAAGTGACGCTTGTCGTGAACTGACTGAACAACTAGCTGACCAACAGAGAAAGACTTTATCTCACGATGCATGGTTAA
CTGAACAAGTTAACTTGGCTTTTGAGAAGTTTGACTCAGGAAAAGCCACTTTTGTTGATCACGAATCAGCTAAATCACGT
ATTGCTGAGCGCAAAGCTAAAATCCGTAACCGAGGCAAATTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|