Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 35226..35751 Replicon plasmid pCFSAN000006
Accession NZ_CP011395
Organism Salmonella enterica subsp. enterica serovar Enteritidis str. 18569

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag SEE18569_RS22935 Protein ID WP_001159863.1
Coordinates 35446..35751 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag SEE18569_RS22930 Protein ID WP_000813641.1
Coordinates 35226..35444 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SEE18569_RS22905 30840..31226 + 387 WP_000751876.1 YgiW/YdeI family stress tolerance OB fold protein -
SEE18569_RS24545 31279..31440 + 162 WP_015059604.1 hypothetical protein -
SEE18569_RS22910 31767..32756 - 990 WP_000461382.1 RepB family plasmid replication initiator protein -
SEE18569_RS25035 33250..33545 - 296 Protein_46 cytoplasmic protein -
SEE18569_RS25580 33557..33985 + 429 Protein_47 hypothetical protein -
SEE18569_RS22925 34029..34550 - 522 WP_077681952.1 hypothetical protein -
SEE18569_RS22930 35226..35444 + 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
SEE18569_RS22935 35446..35751 + 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
SEE18569_RS22940 35753..36043 + 291 WP_001266176.1 hypothetical protein -
SEE18569_RS22945 36040..36561 + 522 WP_000198608.1 hypothetical protein -
SEE18569_RS22950 36596..37378 + 783 WP_000082169.1 site-specific integrase -
SEE18569_RS22955 37387..38100 + 714 WP_000545756.1 EAL domain-containing protein -
SEE18569_RS22960 38104..38613 + 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
SEE18569_RS22965 38607..39092 + 486 WP_000905606.1 membrane protein -
SEE18569_RS24555 39369..39656 - 288 WP_071530243.1 hypothetical protein -
SEE18569_RS22975 39812..40372 + 561 WP_000900095.1 inverse autotransporter beta domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..59336 59336


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T54188 WP_001159863.1 NZ_CP011395:35446-35751 [Salmonella enterica subsp. enterica serovar Enteritidis str. 18569]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T54188 NZ_CP011395:35446-35751 [Salmonella enterica subsp. enterica serovar Enteritidis str. 18569]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT54188 WP_000813641.1 NZ_CP011395:35226-35444 [Salmonella enterica subsp. enterica serovar Enteritidis str. 18569]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT54188 NZ_CP011395:35226-35444 [Salmonella enterica subsp. enterica serovar Enteritidis str. 18569]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References