Detailed information of TA system TA054187

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pemK-mazE/MazF-ParD
• Location: 2995406..2996032
• Replicon: chromosome
• Accession: NZ_CP011388
• Organism: Paenibacillus swuensis strain DY6

Toxin (Protein)

• Gene name: pemK
• Uniprot ID: A0A172TJQ7
• Locus tag: SY83_RS13190
• Protein ID: WP_068607207.1
• Coordinates: 2995682..2996032 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: SY83_RS13185
• Protein ID: WP_197480051.1
• Coordinates: 2995406..2995678 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SY83_RS13170	2991268..2991801	-	534	WP_068607200.1	hypothetical protein	-
SY83_RS13175	2992549..2993811	+	1263	WP_068607202.1	outer membrane lipoprotein-sorting protein	-
SY83_RS13180	2994001..2995200	+	1200	WP_068607203.1	alanine racemase	-
SY83_RS13185	2995406..2995678	+	273	WP_197480051.1	CopG family ribbon-helix-helix protein	Antitoxin
SY83_RS13190	2995682..2996032	+	351	WP_068607207.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
SY83_RS13195	2996151..2998397	+	2247	WP_068607209.1	RNA-binding transcriptional accessory protein	-
SY83_RS13200	2998479..2998664	-	186	WP_068607210.1	cortex morphogenetic protein CmpA	-
SY83_RS13205	2998796..2999152	-	357	WP_068607212.1	hydrolase/acyltransferase	-
SY83_RS13210	2999277..2999741	+	465	WP_068607215.1	SprT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-110)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-43)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12922.84 Da
• Isoelectric Point: 4.8943

>T54187 WP_068607207.1 NZ_CP011388:2995682-2996032 [Paenibacillus swuensis]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIEAETHGFDRDSVILLEQI
RTIDKQRLTDKITHLDEETMRKVDDSLQISVGLIEF

Nucleotide

• Length: 351 bp

>T54187 NZ_CP011388:2995682-2996032 [Paenibacillus swuensis]
TTGATTGTGAAACGCGGCGATGTATTTTTTGCCGACCTTTCTCCGGTCGTCGGGTCCGAGCAAGGCGGAGTCCGTCCGGT
GTTGGTCATCCAGAATGATATTGGCAATCGCTTCAGTCCGACTGTGATTGTAGCGGCCATCACCGCTCAGATCCAGAAGG
CGAAGCTTCCGACGCATGTCGAGATTGAGGCGGAAACGCACGGTTTTGACAGGGACTCGGTAATTCTGCTTGAACAGATT
CGAACGATCGATAAGCAGCGATTAACGGATAAGATTACCCACCTGGACGAAGAAACGATGCGTAAAGTGGATGATTCGTT
ACAGATTAGCGTGGGGTTAATTGAATTTTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10603.16 Da
• Isoelectric Point: 5.8768

>AT54187 WP_197480051.1 NZ_CP011388:2995406-2995678 [Paenibacillus swuensis]
MHNTKRIMISLPDYLLQEVDGIVEKENSNRSEFIRQAMRLYLTERKKRQLRDSMQRGYMEMAKINLNMASEAFYAEEDAD
SILDRLVSGV

Nucleotide

• Length: 273 bp

>AT54187 NZ_CP011388:2995406-2995678 [Paenibacillus swuensis]
ATGCATAACACGAAGAGAATTATGATTAGTTTGCCGGATTATCTACTTCAGGAGGTCGACGGGATCGTGGAAAAAGAAAA
TTCCAACCGCAGTGAATTTATCCGTCAAGCCATGAGATTGTATCTCACCGAACGTAAGAAAAGGCAGCTTCGTGATTCGA
TGCAACGCGGTTATATGGAGATGGCCAAAATCAACCTAAACATGGCATCGGAAGCGTTCTATGCGGAGGAAGATGCGGAT
AGCATTCTGGACCGTCTAGTTAGCGGGGTGTAA

Structures

Toxin

• AlphaFold DB: A0A172TJQ7