Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 4092927..4093486 Replicon chromosome
Accession NZ_CP011382
Organism Calothrix sp. 336/3

Toxin (Protein)


Gene name vapC Uniprot ID A0A0T7BUL5
Locus tag IJ00_RS17090 Protein ID WP_035154825.1
Coordinates 4093148..4093486 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0T7BUF9
Locus tag IJ00_RS17085 Protein ID WP_035154823.1
Coordinates 4092927..4093151 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IJ00_RS17060 4088071..4088865 + 795 WP_035154811.1 fumarylacetoacetate hydrolase family protein -
IJ00_RS17065 4088936..4089415 - 480 WP_035154813.1 hypothetical protein -
IJ00_RS17070 4089521..4089718 - 198 WP_035154818.1 hypothetical protein -
IJ00_RS17075 4090256..4091539 + 1284 WP_035159199.1 serine hydroxymethyltransferase -
IJ00_RS17080 4091602..4092861 + 1260 WP_035154821.1 competence/damage-inducible protein A -
IJ00_RS17085 4092927..4093151 + 225 WP_035154823.1 DUF433 domain-containing protein Antitoxin
IJ00_RS17090 4093148..4093486 + 339 WP_035154825.1 DUF5615 family PIN-like protein Toxin
IJ00_RS17095 4093642..4094259 + 618 WP_035154827.1 DedA family protein -
IJ00_RS17100 4094399..4096150 - 1752 WP_035154828.1 ABC transporter ATP-binding protein/permease -
IJ00_RS17105 4096286..4096894 - 609 WP_035154830.1 hypothetical protein -
IJ00_RS17110 4097400..4098398 + 999 WP_035154832.1 UDP-glucose 4-epimerase GalE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(1-78)

Antitoxin

Protein of unknown function DUF433

(8-63)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12307.14 Da        Isoelectric Point: 4.0177

>T54185 WP_035154825.1 NZ_CP011382:4093148-4093486 [Calothrix sp. 336/3]
MRIWIDAQLSPAIATWISNTFSITALALRDIGLRDAEDDEIFELAKAQGIILITKDSDFVDLLNRLGSPPKVIWLTCGNT
SNARLQEILSQNLLTALELLQAGEDLVEISGL

Download         Length: 339 bp

>T54185 NZ_CP011382:4093148-4093486 [Calothrix sp. 336/3]
ATGAGGATTTGGATAGATGCTCAATTATCCCCTGCGATCGCAACTTGGATAAGCAACACTTTTTCCATAACGGCATTAGC
CTTGCGTGATATTGGTTTGAGAGATGCTGAAGACGATGAAATTTTTGAGCTAGCCAAGGCTCAAGGCATTATACTCATAA
CCAAAGACAGCGACTTTGTTGATCTGCTTAATCGCCTTGGTTCACCACCAAAAGTTATCTGGCTAACTTGTGGAAATACT
TCAAATGCTCGGTTGCAAGAGATACTGAGTCAGAATTTGCTCACAGCACTTGAACTTCTACAAGCAGGTGAAGATTTGGT
AGAAATCAGTGGACTCTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8215.66 Da        Isoelectric Point: 5.7582

>AT54185 WP_035154823.1 NZ_CP011382:4092927-4093151 [Calothrix sp. 336/3]
MQDLLERVTINPKQCGGRPCIRGMRIRVSDVLDLFVAGLSAEQILAEMPDLEADDLKAALLYASRRLNHPVLVV

Download         Length: 225 bp

>AT54185 NZ_CP011382:4092927-4093151 [Calothrix sp. 336/3]
ATGCAAGACTTATTGGAAAGAGTAACAATCAATCCTAAGCAATGTGGTGGTCGTCCCTGTATTCGGGGTATGCGAATTCG
AGTATCTGACGTGCTGGATTTGTTTGTTGCGGGACTAAGTGCTGAACAAATCCTGGCAGAAATGCCTGACCTAGAGGCAG
ATGACCTGAAAGCAGCACTTTTGTATGCTTCACGTAGGCTGAATCATCCGGTTCTGGTTGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T7BUL5

Antitoxin

Source ID Structure
AlphaFold DB A0A0T7BUF9

References