Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 2389361..2389862 Replicon chromosome
Accession NZ_CP011382
Organism Calothrix sp. 336/3

Toxin (Protein)


Gene name - Uniprot ID A0A0T7BR86
Locus tag IJ00_RS10060 Protein ID WP_035152623.1
Coordinates 2389593..2389862 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0T7BRS4
Locus tag IJ00_RS10055 Protein ID WP_035152621.1
Coordinates 2389361..2389612 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IJ00_RS10035 2384634..2385179 + 546 WP_046814784.1 DUF2703 domain-containing protein -
IJ00_RS10040 2385225..2385809 + 585 WP_035152615.1 RNA polymerase sigma factor SigZ -
IJ00_RS10045 2385905..2386360 - 456 WP_035152618.1 hypothetical protein -
IJ00_RS27710 2387234..2389306 - 2073 WP_082127305.1 DUF4157 domain-containing protein -
IJ00_RS10055 2389361..2389612 - 252 WP_035152621.1 CopG family transcriptional regulator Antitoxin
IJ00_RS10060 2389593..2389862 - 270 WP_035152623.1 BrnT family toxin Toxin
IJ00_RS27085 2389893..2393009 - 3117 WP_052754439.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-80)

Antitoxin

CopG antitoxin

(4-69)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10478.83 Da        Isoelectric Point: 5.8919

>T54184 WP_035152623.1 NZ_CP011382:c2389862-2389593 [Calothrix sp. 336/3]
VEFEFDDSKSQSNLVKHGINFPDAQELWTDPDRVEIPARTEDEPRFLIIGKIAQKCWSAVITYRENKVRIISVRRSRKEE
VAIYESNRI

Download         Length: 270 bp

>T54184 NZ_CP011382:c2389862-2389593 [Calothrix sp. 336/3]
GTGGAATTTGAATTTGACGACTCTAAAAGCCAATCCAACCTAGTAAAACATGGAATCAACTTCCCAGATGCACAAGAACT
CTGGACTGATCCAGATCGAGTAGAAATTCCGGCTCGAACAGAAGACGAACCGAGATTTCTGATCATAGGCAAAATTGCTC
AGAAATGCTGGTCAGCCGTCATTACCTATCGAGAAAACAAAGTGCGGATTATTTCAGTCCGGCGATCGCGAAAAGAAGAG
GTAGCCATTTATGAAAGCAACAGAATTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9808.13 Da        Isoelectric Point: 5.1679

>AT54184 WP_035152621.1 NZ_CP011382:c2389612-2389361 [Calothrix sp. 336/3]
MKATEFDAKFDQEEDITEFLDLSQAKRPGHEQKRVNVDFPAWMIEALDYEAKRLGVTRQSIIKVWLAERLEKSAHRNIQY
IDV

Download         Length: 252 bp

>AT54184 NZ_CP011382:c2389612-2389361 [Calothrix sp. 336/3]
ATGAAAGCAACAGAATTTGATGCCAAATTCGATCAAGAAGAAGACATCACCGAATTCTTAGACCTTTCCCAAGCCAAACG
TCCTGGCCATGAACAGAAACGAGTCAACGTCGATTTTCCAGCTTGGATGATTGAAGCATTAGATTATGAAGCCAAACGAT
TAGGTGTCACCCGTCAGTCAATCATTAAGGTATGGCTTGCAGAACGGCTGGAAAAATCAGCTCACAGAAACATCCAATAT
ATAGACGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T7BR86

Antitoxin

Source ID Structure
AlphaFold DB A0A0T7BRS4

References