Detailed information of TA system TA054171

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 257805..258373
• Replicon: chromosome
• Accession: NZ_CP011371
• Organism: Caldimonas brevitalea strain DSM 7029

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: AAW51_RS01135
• Protein ID: WP_047193154.1
• Coordinates: 258083..258373 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0G3BC78
• Locus tag: AAW51_RS01130
• Protein ID: WP_047193153.1
• Coordinates: 257805..258095 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AAW51_RS01105 (AAW51_0221)	252877..253332	-	456	WP_047193148.1	DUF2214 family protein	-
AAW51_RS01110 (AAW51_0222)	253379..254302	-	924	WP_047193149.1	LysR family transcriptional regulator	-
AAW51_RS01115 (AAW51_0223)	254538..255254	+	717	WP_047193150.1	haloacid dehalogenase type II	-
AAW51_RS01120 (AAW51_0224)	255251..256006	+	756	WP_047193151.1	sulfite exporter TauE/SafE family protein	-
AAW51_RS01125 (AAW51_0225)	256053..257633	+	1581	WP_047193152.1	malate synthase A	-
AAW51_RS01130 (AAW51_0226)	257805..258095	+	291	WP_047193153.1	CopG family ribbon-helix-helix protein	Antitoxin
AAW51_RS01135 (AAW51_0227)	258083..258373	+	291	WP_047193154.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AAW51_RS01140 (AAW51_0228)	258481..259239	+	759	WP_047193155.1	class II glutamine amidotransferase	-
AAW51_RS01145 (AAW51_0229)	259252..261180	-	1929	WP_053013230.1	sensor histidine kinase	-
AAW51_RS01150 (AAW51_0230)	261146..261799	-	654	WP_047193156.1	response regulator transcription factor	-
AAW51_RS01155 (AAW51_0231)	262060..262560	+	501	WP_047193157.1	(2Fe-2S)-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (10-46)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10904.52 Da
• Isoelectric Point: 7.2006

>T54171 WP_047193154.1 NZ_CP011371:258083-258373 [Caldimonas brevitalea]
MPEIRYAPAALRDLERLRTFLQSKAPDAAQRAGRAVAQALKVLGQQPHIGRPVEEMPIEYREWLIDFGDSGYVALYRIDG
DLVTILAVRHQREVGY

Nucleotide

• Length: 291 bp

>T54171 NZ_CP011371:258083-258373 [Caldimonas brevitalea]
ATGCCGGAAATAAGATACGCACCCGCCGCCTTGCGTGACCTGGAGCGGCTGCGCACCTTCCTTCAATCGAAAGCGCCCGA
CGCTGCGCAACGAGCCGGTCGCGCCGTTGCCCAGGCCCTGAAGGTCCTCGGCCAGCAGCCCCACATTGGACGGCCGGTCG
AGGAGATGCCGATCGAGTACCGCGAATGGCTCATTGACTTCGGCGACAGCGGATATGTCGCGCTGTACCGCATCGACGGT
GACCTGGTCACCATCCTGGCCGTCCGCCACCAGCGCGAAGTCGGCTACTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 11254.61 Da
• Isoelectric Point: 5.2761

>AT54171 WP_047193153.1 NZ_CP011371:257805-258095 [Caldimonas brevitalea]
MTTAGVRPVAVKIDDDLKERIQRLAQARARTPHWIMKEAISQYVEREEKHEAFRQAGLKAWEEYRATGQYARPEEVEAWL
ESWGTEDEQPAPECRK

Nucleotide

• Length: 291 bp

>AT54171 NZ_CP011371:257805-258095 [Caldimonas brevitalea]
ATGACCACGGCCGGCGTTCGCCCAGTTGCCGTCAAGATCGATGACGACCTCAAGGAGCGCATCCAACGCCTCGCTCAGGC
ACGTGCGCGCACGCCCCACTGGATCATGAAGGAGGCGATTTCCCAGTACGTCGAACGCGAGGAGAAACACGAGGCGTTCC
GGCAAGCCGGGCTCAAGGCGTGGGAGGAGTATCGGGCAACCGGCCAATACGCGCGCCCCGAGGAAGTCGAGGCATGGCTC
GAAAGCTGGGGCACCGAGGATGAACAGCCGGCACCGGAATGCCGGAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0G3BC78