Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 565154..566272 Replicon chromosome
Accession NZ_CP011367
Organism Thioalkalivibrio versutus strain D301

Toxin (Protein)


Gene name - Uniprot ID A0A0G3FZF2
Locus tag TVD_RS02735 Protein ID WP_047250747.1
Coordinates 565526..566272 (+) Length 249 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0G3G1T2
Locus tag TVD_RS02730 Protein ID WP_024326552.1
Coordinates 565154..565513 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TVD_RS02705 561165..562530 - 1366 Protein_535 GntP family permease -
TVD_RS02710 562654..563226 + 573 WP_047250744.1 Spy/CpxP family protein refolding chaperone -
TVD_RS02715 563300..563953 + 654 WP_047250745.1 cupin domain-containing protein -
TVD_RS02720 564011..564256 + 246 Protein_538 sodium:proline symporter -
TVD_RS13920 564180..564605 - 426 WP_081644454.1 GIY-YIG nuclease family protein -
TVD_RS02725 564602..564928 - 327 WP_024326553.1 DUF3634 family protein -
TVD_RS02730 565154..565513 + 360 WP_024326552.1 MbcA/ParS/Xre antitoxin family protein Antitoxin
TVD_RS02735 565526..566272 + 747 WP_047250747.1 RES family NAD+ phosphorylase Toxin
TVD_RS02740 566408..567382 - 975 WP_082119139.1 hypothetical protein -
TVD_RS02745 567614..568069 - 456 WP_047250749.1 hypothetical protein -
TVD_RS02750 568598..569221 + 624 WP_205622094.1 hypothetical protein -
TVD_RS02755 569536..570447 + 912 WP_047250751.1 D-hexose-6-phosphate mutarotase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(62-208)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-117)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 28386.23 Da        Isoelectric Point: 9.2332

>T54169 WP_047250747.1 NZ_CP011367:565526-566272 [Thioalkalivibrio versutus]
MSDWDALVEAAPRVTLRGEVLRLVESQEQVATNQIVSSLDRQAVLEEMLEATKPPRRPGTERLHYLLATPFRYPPLRHGS
RFGRRHEPSLFYGALRERTVLAEAAYYRFVFWHGMATPPPRKLDTQHTLFAARYQSPNGLQLHQPPFAEHADLLRHPADY
QATQALGAALREAGIDLFEYPSARDHEAGLNLGLFNARPFTRNKPTRQDPWLCQLTADHVRFLKPRDGALHDFPLTQFHY
QGRLPLPA

Download         Length: 747 bp

>T54169 NZ_CP011367:565526-566272 [Thioalkalivibrio versutus]
ATGTCGGACTGGGATGCCCTGGTCGAAGCGGCGCCGCGTGTCACGCTGAGAGGGGAGGTCCTGCGCCTGGTGGAGAGCCA
GGAGCAGGTTGCCACCAACCAGATTGTCAGCTCGCTCGACCGCCAGGCCGTTCTGGAAGAGATGCTGGAGGCCACCAAGC
CGCCCCGGCGCCCGGGTACGGAACGGCTGCACTACCTGCTGGCGACGCCGTTTCGCTACCCGCCGCTACGTCACGGATCG
CGCTTCGGCCGTCGCCACGAACCCAGCCTGTTCTACGGCGCCCTGCGCGAGCGCACGGTCCTCGCCGAGGCGGCCTACTA
CCGGTTTGTGTTCTGGCATGGCATGGCGACCCCGCCACCGCGCAAGCTCGATACCCAGCACACGTTGTTCGCCGCACGCT
ACCAGAGCCCCAATGGCTTGCAGCTCCATCAGCCCCCGTTCGCTGAACACGCGGACCTGTTGCGTCATCCCGCCGACTAT
CAGGCCACCCAGGCCCTGGGCGCCGCGCTGCGCGAGGCCGGCATCGACCTGTTCGAATACCCGTCCGCCCGCGATCACGA
GGCCGGCCTGAACCTCGGGCTCTTCAATGCGCGCCCGTTTACCCGCAACAAACCCACGCGCCAGGATCCCTGGCTGTGCC
AGCTCACCGCCGACCACGTCCGTTTCCTCAAGCCCCGCGACGGCGCCCTGCACGACTTTCCCCTGACCCAGTTCCACTAC
CAGGGCCGGCTGCCGCTACCCGCCTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 12670.58 Da        Isoelectric Point: 7.3582

>AT54169 WP_024326552.1 NZ_CP011367:565154-565513 [Thioalkalivibrio versutus]
MSATEGLAAERADVLREALVNAGKALGLTQAELGEVIGRGRTDISRGNVDPASKPGELALLLIRCYRALYVLTGGDASAM
KHWMQTHNHHIGGVPAEQIRTVQGLVGVLEYLDAIRGKL

Download         Length: 360 bp

>AT54169 NZ_CP011367:565154-565513 [Thioalkalivibrio versutus]
ATGAGCGCTACAGAAGGCCTGGCCGCGGAACGCGCGGATGTCCTGCGCGAGGCGCTGGTCAATGCCGGCAAGGCGCTGGG
CCTGACCCAGGCGGAGCTGGGAGAGGTGATCGGACGCGGGCGTACGGACATCAGCCGGGGCAACGTCGACCCGGCCAGCA
AGCCGGGTGAGCTGGCGCTGTTGCTGATTCGCTGCTATCGCGCCCTGTACGTCCTGACCGGCGGGGATGCCAGTGCGATG
AAACACTGGATGCAGACGCACAACCACCACATCGGCGGCGTGCCCGCCGAGCAGATCCGCACGGTGCAGGGCCTGGTGGG
CGTGCTGGAGTATCTTGACGCGATCCGCGGCAAGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3FZF2

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3G1T2

References