Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3421855..3422447 Replicon chromosome
Accession NZ_CP011364
Organism Edwardsiella sp. EA181011

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag QY76_RS15140 Protein ID WP_012847872.1
Coordinates 3422244..3422447 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A034T4H2
Locus tag QY76_RS15135 Protein ID WP_034163649.1
Coordinates 3421855..3422223 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QY76_RS15125 3417108..3418292 + 1185 WP_034163646.1 efflux RND transporter periplasmic adaptor subunit -
QY76_RS15130 3418336..3421488 + 3153 WP_034163648.1 multidrug efflux RND transporter permease subunit -
QY76_RS15135 3421855..3422223 + 369 WP_034163649.1 Hha toxicity modulator TomB Antitoxin
QY76_RS15140 3422244..3422447 + 204 WP_012847872.1 hemolysin expression modulator Hha Toxin
QY76_RS15145 3422948..3423277 + 330 WP_034163651.1 MGMT family protein -
QY76_RS15150 3423386..3424252 + 867 WP_045426178.1 acyl-CoA thioesterase II -
QY76_RS15155 3424287..3425567 - 1281 WP_034163814.1 ammonium transporter AmtB -
QY76_RS15160 3425588..3425926 - 339 WP_045426180.1 P-II family nitrogen regulator -
QY76_RS15165 3426198..3426659 - 462 WP_045426183.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T54163 WP_012847872.1 NZ_CP011364:3422244-3422447 [Edwardsiella sp. EA181011]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T54163 NZ_CP011364:3422244-3422447 [Edwardsiella sp. EA181011]
ATGACCAAGATCGATTATCTGATGAAGCTGCGTAAATGCACGACGCTGGATACTCTGGAACGCGTGATCGAAAAGAATAA
ATACGAACTTTCAGATGATGAACTAGAAATTTTTTATTCTGCTGCAGATCATCGACTAGCCGAATTAACTATGAATAAGC
TATACGACAAAATTCCGGCAGAAGTCTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14118.85 Da        Isoelectric Point: 6.2108

>AT54163 WP_034163649.1 NZ_CP011364:3421855-3422223 [Edwardsiella sp. EA181011]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPRHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT54163 NZ_CP011364:3421855-3422223 [Edwardsiella sp. EA181011]
ATGGATGAGTATACTTCTTATCAGCATGACATCGCAGAGTTAAAATACCTGTGTGATTCTCTGTATCATCAGGGAATAGA
TGTCCTGGGAGAGAGCCATCACGGCTGGGTCAGCGACCCGACGGCAAAGGTAAACCTACAGCTTAACGAGCTGATTGAGC
ATATTGCCAGCGTCGCACAATCATTTAAGATCAAATATCCGCGTCATTCGGATTTAGCCGAAATACTGGATGATTATCTG
GATGAAACCTACGCCCTGTTTGGTGCCTATAGCGTCAGTGAAACGGCGCTCAGACACTGGCTGCGTACCAAACGCCGTGT
GGCATACTGCCTGGCGCATGAAAAGCGCAATGCGGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB A0A034T4H2

References