Detailed information of TA system TA054154

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 1271427..1272090
• Replicon: chromosome
• Accession: NZ_CP011364
• Organism: Edwardsiella sp. EA181011

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: QY76_RS05650
• Protein ID: WP_071844118.1
• Coordinates: 1271674..1272090 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D0ZDY6
• Locus tag: QY76_RS05645
• Protein ID: WP_012849755.1
• Coordinates: 1271427..1271693 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QY76_RS05625	1266926..1267575	-	650	Protein_1101	hemolysin III family protein	-
QY76_RS05630	1268185..1269057	+	873	WP_034164695.1	nucleoside-specific channel-forming protein Tsx	-
QY76_RS05635	1269214..1270038	+	825	WP_034164693.1	shikimate 5-dehydrogenase	-
QY76_RS05640	1270080..1271078	-	999	WP_034164692.1	tRNA-modifying protein YgfZ	-
QY76_RS05645	1271427..1271693	+	267	WP_012849755.1	FAD assembly factor SdhE	Antitoxin
QY76_RS05650	1271674..1272090	+	417	WP_071844118.1	protein YgfX	Toxin
QY76_RS05655	1272115..1272627	-	513	WP_034164689.1	flavodoxin FldB	-
QY76_RS05660	1272779..1273678	+	900	WP_034164688.1	site-specific tyrosine recombinase XerD	-
QY76_RS05665	1273706..1274422	+	717	WP_045426732.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
QY76_RS05670	1274427..1276160	+	1734	WP_034164685.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16199.00 Da
• Isoelectric Point: 11.6049

>T54154 WP_071844118.1 NZ_CP011364:1271674-1272090 [Edwardsiella sp. EA181011]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSAFWLVLLVAVIFECIRSQRRIARNRGELQLLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGVPCRRRLWLAADSMSREEWGQLRRALLDTGDDRA

Nucleotide

• Length: 417 bp

>T54154 NZ_CP011364:1271674-1272090 [Edwardsiella sp. EA181011]
GTGGTCCTTTGGCGCTGTAACGTTCACGTCTCCTGGCGTACCCAGGTGATGTTTCTGCTGGGGCACGGCGCGCTGGTTTT
GGCGATCCTGCTGGCGCCCTGGCCGGAAAACTACAGCGCATTCTGGCTGGTTCTGCTGGTGGCGGTGATCTTTGAGTGTA
TCCGCAGCCAGCGTCGGATTGCGCGTAACCGCGGTGAGCTGCAGCTGCTGGCGCCGCAGGTGTGGCACTGGCAGCTGCGC
GAGTGGCGCCTGGCCCGGCGCCCCTGGGTTAGCGATCTGGGGGCGCTGCTGATTCTGCAGAGTACCCATGGTGTACCGTG
CCGCCGCCGTCTGTGGCTGGCGGCCGACAGCATGAGCCGAGAAGAGTGGGGGCAGCTGCGCCGCGCGCTGCTCGATACGG
GCGACGATCGCGCATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10318.90 Da
• Isoelectric Point: 5.6951

>AT54154 WP_012849755.1 NZ_CP011364:1271427-1271693 [Edwardsiella sp. EA181011]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Nucleotide

• Length: 267 bp

>AT54154 NZ_CP011364:1271427-1271693 [Edwardsiella sp. EA181011]
ATGGATATCAATAATAAAGCGCGGGTTCACTGGGCGTGCCGCCGCGGAATGCGCGAGCTGGATATCGCGATTATGCCTTT
CTTTGAACATGAGTATGATGCGCTTAACGATGCCGATAAACAGACCTTTGTCCGCCTGCTGGCCTGCGACGATCCTGAGC
TATTTAAATGGCTGATGAACCAGGGTAAGCCGGACGACGCTGATCTGGCCCGTATGATTACGCTGATTCAGACGCGAAAT
AAAGAACGTGGTCCTTTGGCGCTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A034T2Q8