Detailed information of TA system TA054151

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1308662..1309147
• Replicon: chromosome
• Accession: NZ_CP011361
• Organism: Salimicrobium jeotgali strain MJ3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: K2GEP7
• Locus tag: AAV35_RS06575
• Protein ID: WP_008587660.1
• Coordinates: 1308662..1308928 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: K2GCG5
• Locus tag: AAV35_RS06580
• Protein ID: WP_008587661.1
• Coordinates: 1308932..1309147 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AAV35_RS06535	1304038..1304772	+	735	WP_008587644.1	SDR family oxidoreductase	-
AAV35_RS06540	1304882..1305073	+	192	WP_008587647.1	hypothetical protein	-
AAV35_RS06545	1305705..1305923	+	219	WP_008587649.1	helix-turn-helix transcriptional regulator	-
AAV35_RS06550	1305927..1306298	+	372	WP_008587651.1	hypothetical protein	-
AAV35_RS06555	1306745..1307305	+	561	WP_008587653.1	GNAT family N-acetyltransferase	-
AAV35_RS06565	1307872..1308156	+	285	WP_008587656.1	helix-turn-helix transcriptional regulator	-
AAV35_RS06570	1308310..1308561	-	252	WP_008587658.1	hypothetical protein	-
AAV35_RS06575	1308662..1308928	-	267	WP_008587660.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AAV35_RS06580	1308932..1309147	-	216	WP_008587661.1	hypothetical protein	Antitoxin
AAV35_RS06585	1309236..1309472	-	237	WP_073991987.1	transposase	-
AAV35_RS14350	1310371..1310700	-	330	WP_156330840.1	hypothetical protein	-
AAV35_RS06595	1310866..1311216	-	351	WP_008587667.1	hypothetical protein	-
AAV35_RS06600	1311240..1311893	-	654	WP_008587669.1	hypothetical protein	-
AAV35_RS06605	1312800..1313018	+	219	WP_008587671.1	DUF3953 domain-containing protein	-
AAV35_RS06610	1313095..1313379	+	285	WP_008587673.1	hypothetical protein	-
AAV35_RS06615	1313518..1313838	+	321	WP_008587674.1	cupin domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10446.28 Da
• Isoelectric Point: 10.3183

>T54151 WP_008587660.1 NZ_CP011361:c1308928-1308662 [Salimicrobium jeotgali]
MSYQVVYTKKAIKSLKKVDKAQQRLIIAWIEKHLINAKDPRALGKALKEDLKAYWRYRVGDYRILADINDNEIKIIVFNI
GHRKDIYE

Nucleotide

• Length: 267 bp

>T54151 NZ_CP011361:c1308928-1308662 [Salimicrobium jeotgali]
ATGTCCTATCAAGTTGTTTATACAAAAAAAGCAATAAAAAGCCTCAAGAAAGTTGATAAAGCACAACAAAGACTAATTAT
TGCCTGGATAGAAAAACATTTAATCAATGCTAAAGACCCAAGAGCTTTAGGCAAGGCACTCAAAGAGGATTTGAAAGCGT
ATTGGCGCTATCGTGTAGGAGATTATCGCATTTTAGCCGACATCAACGATAATGAAATTAAAATTATTGTTTTTAATATA
GGCCATCGTAAAGACATCTATGAGTAA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 8364.38 Da
• Isoelectric Point: 4.1712

>AT54151 WP_008587661.1 NZ_CP011361:c1309147-1308932 [Salimicrobium jeotgali]
MKTITIRLNKNESQTFEEYAELNNVPLSTLFKKTLEEKMEDEFDMSMITEYEKNTPPATYTHDELKDDLGL

Nucleotide

• Length: 216 bp

>AT54151 NZ_CP011361:c1309147-1308932 [Salimicrobium jeotgali]
ATGAAAACAATAACTATACGTCTGAACAAAAATGAATCGCAAACTTTTGAGGAGTACGCTGAATTGAACAATGTCCCTCT
ATCAACGTTATTTAAAAAAACTCTGGAAGAGAAGATGGAAGACGAATTTGATATGAGCATGATCACAGAATATGAAAAAA
ATACACCTCCTGCTACGTATACGCATGATGAATTAAAAGATGACTTAGGTTTATAG

Structures

Toxin

• AlphaFold DB: K2GEP7

Antitoxin

• AlphaFold DB: K2GCG5