Detailed information of TA system TA054137

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ypjF-yeeU/CbtA-CbeA
• Location: 1244353..1245085
• Replicon: chromosome
• Accession: NZ_CP011359
• Organism: Edwardsiella tarda strain FL95-01

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: AAW15_RS16530
• Protein ID: WP_071842133.1
• Coordinates: 1244353..1244682 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: AAW15_RS05655
• Protein ID: WP_047059512.1
• Coordinates: 1244720..1245085 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AAW15_RS05630	1239480..1240760	-	1281	WP_005294734.1	TRAP transporter large permease subunit	-
AAW15_RS05635	1240757..1241236	-	480	WP_047059506.1	TRAP transporter small permease	-
AAW15_RS05640	1241344..1242375	-	1032	WP_047059508.1	TRAP transporter substrate-binding protein	-
AAW15_RS05645	1242525..1243535	-	1011	WP_047059510.1	LacI family DNA-binding transcriptional regulator	-
AAW15_RS05650	1243755..1243985	-	231	WP_005287810.1	hypothetical protein	-
AAW15_RS16530	1244353..1244682	-	330	WP_071842133.1	TA system toxin CbtA family protein	Toxin
AAW15_RS05655	1244720..1245085	-	366	WP_047059512.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
AAW15_RS16535	1245111..1245332	-	222	WP_071842134.1	DUF987 family protein	-
AAW15_RS05660	1245329..1245871	-	543	WP_047059513.1	DNA repair protein RadC	-
AAW15_RS05665	1245884..1246327	-	444	WP_047059515.1	antirestriction protein	-
AAW15_RS05670	1246358..1247179	-	822	WP_001234409.1	DUF945 domain-containing protein	-
AAW15_RS05675	1247592..1247795	-	204	WP_047059518.1	hypothetical protein	-
AAW15_RS05680	1247842..1248681	-	840	WP_047059520.1	hypothetical protein	-
AAW15_RS05685	1248741..1249175	-	435	WP_047059522.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1244353..1263024	18671

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-108)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12375.15 Da
• Isoelectric Point: 7.2754

>T54137 WP_071842133.1 NZ_CP011359:c1244682-1244353 [Edwardsiella tarda]
MQTISSHPTRATQPCLSPVEIWQRLLTYLLLQHYGLTLNDTPFSNASTIQEHIDAGISLSDAVNFLVEKYGLVRIDRKGF
SWEEQTPYLSVVDILRARRSTGLLKTDVK

Nucleotide

• Length: 330 bp

>T54137 NZ_CP011359:c1244682-1244353 [Edwardsiella tarda]
ATGCAAACCATATCATCACACCCGACACGGGCGACTCAGCCCTGCCTGTCACCTGTTGAAATCTGGCAGCGGCTGCTAAC
TTATCTGTTATTGCAGCACTATGGCCTGACACTGAATGACACACCATTCAGCAATGCCTCCACCATCCAGGAACATATTG
ATGCTGGAATATCGCTCAGTGATGCAGTGAACTTTCTGGTAGAAAAATACGGGCTTGTCCGTATCGATCGGAAAGGATTT
TCGTGGGAAGAACAAACCCCGTATCTTTCCGTAGTGGATATTTTGCGAGCAAGACGCTCTACCGGCTTGCTAAAAACTGA
CGTGAAATAA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13687.50 Da
• Isoelectric Point: 5.5169

>AT54137 WP_047059512.1 NZ_CP011359:c1245085-1244720 [Edwardsiella tarda]
MNNHSESGTKPESPARQLWGLKRDITPCFGARLVQESNRLHYLADRAEFSGAFTDDVAMRLDQAFPLMMKQLELMLTSGE
LNPRHQHCVTLYHNGLICEADTLGSCGYVYIAIYPEQTEPQ

Nucleotide

• Length: 366 bp

>AT54137 NZ_CP011359:c1245085-1244720 [Edwardsiella tarda]
ATGAACAATCACTCAGAATCCGGTACTAAGCCGGAGAGTCCCGCCCGCCAGTTGTGGGGACTGAAGCGCGATATAACACC
TTGTTTTGGGGCTCGTCTGGTTCAGGAAAGCAACCGACTGCACTATCTGGCTGACCGAGCAGAATTTAGCGGGGCGTTCA
CCGATGATGTTGCAATGCGCCTTGACCAGGCATTTCCGCTCATGATGAAACAACTTGAGCTGATGCTGACCAGTGGAGAA
CTTAACCCTCGCCACCAACACTGCGTTACGCTATACCACAACGGCCTCATCTGCGAAGCCGACACACTCGGCTCCTGTGG
CTATGTCTACATTGCTATCTATCCTGAGCAGACTGAGCCGCAATAA