Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 536562..537231 Replicon chromosome
Accession NZ_CP011359
Organism Edwardsiella tarda strain FL95-01

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A7U6Y8
Locus tag AAW15_RS02365 Protein ID WP_005296363.1
Coordinates 536809..537231 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A2A7U0A3
Locus tag AAW15_RS02360 Protein ID WP_005296359.1
Coordinates 536562..536828 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AAW15_RS02340 531806..532456 - 651 WP_005282104.1 hemolysin III family protein -
AAW15_RS02345 533032..533907 + 876 WP_005282096.1 nucleoside-specific channel-forming protein Tsx -
AAW15_RS02350 534118..534942 + 825 WP_005282094.1 shikimate 5-dehydrogenase -
AAW15_RS02355 534995..535990 - 996 WP_005296356.1 tRNA-modifying protein YgfZ -
AAW15_RS02360 536562..536828 + 267 WP_005296359.1 FAD assembly factor SdhE Antitoxin
AAW15_RS02365 536809..537231 + 423 WP_005296363.1 protein YgfX Toxin
AAW15_RS02370 537314..537832 - 519 WP_005282086.1 flavodoxin FldB -
AAW15_RS02375 537970..538869 + 900 WP_005282082.1 site-specific tyrosine recombinase XerD -
AAW15_RS02380 538897..539613 + 717 WP_005282080.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AAW15_RS02385 539618..541351 + 1734 WP_005296366.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-134)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16231.84 Da        Isoelectric Point: 9.3042

>T54136 WP_005296363.1 NZ_CP011359:536809-537231 [Edwardsiella tarda]
VAPWCCNVHVSWRTQVIALLGYGALVLTILLAPWPESYGVSAFWLLLLVVVIFECIRSQRRIARNRGELQYSATGEWRWQ
QREWRLARRPWISDMGVLLLLQSSAGPARRRRLWLAADSMSQEEWSELRALLLNAPETND

Download         Length: 423 bp

>T54136 NZ_CP011359:536809-537231 [Edwardsiella tarda]
GTGGCCCCATGGTGCTGTAATGTCCATGTCTCCTGGCGCACCCAGGTGATCGCGTTGTTGGGATATGGTGCGCTGGTGTT
GACGATCCTCCTGGCCCCCTGGCCTGAGAGTTATGGCGTCAGCGCTTTCTGGTTGCTGCTATTGGTGGTGGTGATCTTCG
AGTGTATCCGTAGCCAGCGCCGTATCGCGCGTAATCGCGGGGAGTTGCAATACAGCGCTACGGGAGAGTGGCGTTGGCAA
CAGCGTGAGTGGCGGCTTGCCCGCCGGCCGTGGATCAGCGATATGGGCGTATTGTTATTGCTACAAAGCAGCGCCGGGCC
GGCACGTCGACGCCGCCTGTGGTTGGCGGCAGACAGTATGAGCCAGGAGGAGTGGAGTGAGTTACGGGCCCTGTTACTGA
ACGCTCCCGAGACCAACGACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10325.96 Da        Isoelectric Point: 5.6819

>AT54136 WP_005296359.1 NZ_CP011359:536562-536828 [Edwardsiella tarda]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDAMSDADKQTFVRLLNCDDPELFKWLMNQGVPEDADLARMITLIQTRN
KARGPMVL

Download         Length: 267 bp

>AT54136 NZ_CP011359:536562-536828 [Edwardsiella tarda]
ATGGATATCAATAATAAAGCACGGGTTCACTGGGCATGCCGCCGCGGAATGCGTGAGCTGGACATCGCCATTATGCCCTT
CTTCGAGCATGAGTATGATGCGATGAGTGACGCCGATAAGCAGACGTTTGTCCGCCTGCTGAACTGTGATGATCCCGAGC
TGTTCAAGTGGCTGATGAACCAAGGCGTGCCGGAGGATGCCGATCTGGCACGGATGATTACCCTGATTCAGACGCGAAAT
AAAGCACGTGGCCCCATGGTGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A7U6Y8

Antitoxin

Source ID Structure
AlphaFold DB A0A2A7U0A3

References