Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-CC2985
Location 1699470..1700004 Replicon chromosome
Accession NZ_CP011344
Organism Citromicrobium sp. JL477

Toxin (Protein)


Gene name parE Uniprot ID A0A8D4CKP4
Locus tag WG74_RS08130 Protein ID WP_010238641.1
Coordinates 1699714..1700004 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A8D3Z0H4
Locus tag WG74_RS08125 Protein ID WP_010238642.1
Coordinates 1699470..1699721 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WG74_RS08100 1694879..1695517 + 639 WP_010238654.1 ribonuclease HII -
WG74_RS08105 1695514..1696422 + 909 WP_010238653.1 SDR family NAD(P)-dependent oxidoreductase -
WG74_RS08110 1696501..1697427 + 927 WP_010238650.1 calcium/sodium antiporter -
WG74_RS08115 1697713..1698741 + 1029 WP_192807553.1 site-specific DNA-methyltransferase -
WG74_RS08120 1698917..1699438 + 522 WP_010238644.1 hypothetical protein -
WG74_RS08125 1699470..1699721 + 252 WP_010238642.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
WG74_RS08130 1699714..1700004 + 291 WP_010238641.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WG74_RS08135 1700285..1701397 + 1113 WP_010238640.1 dihydropteroate synthase -
WG74_RS08140 1701402..1702160 - 759 WP_010238639.1 SDR family oxidoreductase -
WG74_RS08145 1702221..1702736 - 516 WP_010238638.1 hemerythrin domain-containing protein -
WG74_RS08150 1702817..1704235 - 1419 WP_010238637.1 sigma-54 dependent transcriptional regulator -
WG74_RS16435 1704434..1704574 + 141 WP_010238636.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(7-81)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11107.68 Da        Isoelectric Point: 7.3597

>T54124 WP_010238641.1 NZ_CP011344:1699714-1700004 [Citromicrobium sp. JL477]
VRELRLTRKAAADLSDIADFTIAEFGIEQAGRYRDQFARCFASLLDNPFLGRSANELAPGLRRIRQQAHVVFYQPSEEVI
LVVRVLHHRMDFEQHL

Download         Length: 291 bp

>T54124 NZ_CP011344:1699714-1700004 [Citromicrobium sp. JL477]
GTGCGTGAGCTGCGGCTGACCCGAAAGGCGGCGGCCGATCTCTCCGACATTGCCGATTTTACCATTGCCGAGTTCGGGAT
CGAGCAGGCGGGCAGGTATCGCGACCAGTTCGCCAGATGCTTCGCCTCGCTGCTCGACAATCCCTTTTTGGGGCGAAGCG
CGAACGAACTCGCGCCCGGTTTGCGGCGTATCCGGCAGCAGGCGCATGTCGTGTTCTACCAGCCCTCGGAAGAGGTGATT
CTAGTTGTCCGCGTGCTCCACCACCGAATGGATTTCGAGCAGCATTTGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9296.27 Da        Isoelectric Point: 4.6461

>AT54124 WP_010238642.1 NZ_CP011344:1699470-1699721 [Citromicrobium sp. JL477]
MATIRKTITLSDTQDAWIKRQIAEGGFTNDSEYIRDLVRRDQEGQEKLSGLRQAIAEGLDSGVSDRSLDDIWTEAEKRAA
ARA

Download         Length: 252 bp

>AT54124 NZ_CP011344:1699470-1699721 [Citromicrobium sp. JL477]
ATGGCCACCATCCGCAAGACCATCACGCTCAGCGACACGCAGGACGCGTGGATCAAGCGTCAGATTGCTGAGGGCGGGTT
CACCAACGACAGCGAATATATCCGCGATCTCGTCCGCCGCGATCAGGAGGGGCAGGAGAAGCTGTCCGGGTTGCGGCAGG
CGATTGCCGAGGGGCTGGACAGCGGCGTGAGCGACCGCTCGCTCGACGACATCTGGACCGAGGCAGAGAAGCGCGCAGCC
GCCCGTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References