Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 1626327..1626853 | Replicon | chromosome |
| Accession | NZ_CP011343 | ||
| Organism | Escherichia coli K-12 substr. GM4792 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | U069_RS08090 | Protein ID | WP_000323025.1 |
| Coordinates | 1626327..1626614 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | U069_RS08095 | Protein ID | WP_000534858.1 |
| Coordinates | 1626614..1626853 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| U069_RS08050 | 1621351..1621566 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| U069_RS25865 | 1621786..1621956 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| U069_RS08055 | 1622320..1622535 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| U069_RS08060 | 1622836..1623048 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| U069_RS25410 | 1623103..1623192 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| U069_RS08065 | 1623470..1624222 | - | 753 | WP_001047135.1 | antitermination protein | - |
| U069_RS08070 | 1624236..1625285 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| U069_RS08075 | 1625287..1625565 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| U069_RS08080 | 1625632..1625883 | - | 252 | WP_000980994.1 | hypothetical protein | - |
| U069_RS08085 | 1626100..1626255 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| U069_RS08090 | 1626327..1626614 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| U069_RS08095 | 1626614..1626853 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| U069_RS23580 | 1626878..1627183 | + | 306 | WP_001326990.1 | hypothetical protein | - |
| U069_RS08100 | 1627386..1627718 | + | 333 | WP_001301033.1 | protein FlxA | - |
| U069_RS22885 | 1628155..1628304 | - | 150 | WP_011443592.1 | hypothetical protein | - |
| U069_RS08105 | 1628339..1628617 | - | 279 | Protein_1555 | hypothetical protein | - |
| U069_RS08110 | 1628601..1628831 | - | 231 | WP_000920568.1 | dicB transcriptional regulator DicC | - |
| U069_RS08115 | 1628915..1629322 | + | 408 | WP_000448564.1 | DNA-binding transcriptional dual regulator DicA | - |
| U069_RS08120 | 1629489..1629644 | + | 156 | WP_000379575.1 | DUF1391 family protein | - |
| U069_RS08125 | 1629804..1630022 | + | 219 | WP_001171942.1 | hypothetical protein | - |
| U069_RS08135 | 1630590..1630778 | + | 189 | WP_000854559.1 | cell division inhibition protein DicB | - |
| U069_RS08140 | 1630775..1630966 | + | 192 | WP_001083297.1 | lysis protein YdfD | - |
| U069_RS23595 | 1631059..1631826 | + | 768 | Protein_1562 | exonuclease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1600970..1637725 | 36755 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T54099 WP_000323025.1 NZ_CP011343:c1626614-1626327 [Escherichia coli K-12]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T54099 NZ_CP011343:c1626614-1626327 [Escherichia coli K-12]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT54099 WP_000534858.1 NZ_CP011343:c1626853-1626614 [Escherichia coli K-12]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT54099 NZ_CP011343:c1626853-1626614 [Escherichia coli K-12]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|