Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type VII Classification (family/domain) HepT-MntA/HepT(toxin)
Location 4659010..4659757 Replicon chromosome
Accession NZ_CP011339
Organism Microcystis panniformis FACHB-1757

Toxin (Protein)


Gene name hepT Uniprot ID I4HG17
Locus tag VL20_RS22120 Protein ID WP_002791882.1
Coordinates 4659010..4659408 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID -
Locus tag VL20_RS22125 Protein ID WP_284525888.1
Coordinates 4659401..4659757 (+) Length 119 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VL20_RS22095 (VL20_5350) 4654276..4655139 - 864 WP_052277817.1 WYL domain-containing protein -
VL20_RS22100 (VL20_5351) 4655239..4657404 + 2166 WP_052277818.1 type I-D CRISPR-associated helicase Cas3' -
VL20_RS22105 (VL20_5352) 4657451..4657693 + 243 WP_052277819.1 hypothetical protein -
VL20_RS22110 (VL20_5353) 4658039..4658386 + 348 WP_002742891.1 hypothetical protein -
VL20_RS22115 (VL20_5354) 4658549..4658968 + 420 WP_002742890.1 nucleotidyltransferase domain-containing protein -
VL20_RS22120 (VL20_5355) 4659010..4659408 + 399 WP_002791882.1 DUF86 domain-containing protein Toxin
VL20_RS22125 (VL20_5356) 4659401..4659757 + 357 WP_284525888.1 nucleotidyltransferase domain-containing protein Antitoxin
VL20_RS33180 (VL20_5357) 4659944..4660087 + 144 WP_002742887.1 hypothetical protein -
VL20_RS22130 (VL20_5358) 4660080..4663523 + 3444 WP_052277820.1 type I-D CRISPR-associated protein Cas10d/Csc3 -
VL20_RS22135 (VL20_5359) 4663541..4664542 + 1002 WP_052277821.1 type I-D CRISPR-associated protein Cas7/Csc2 -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4653008..4654204 1196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-117)

Antitoxin

(15-113)


Sequences


Toxin        


Download         Length: 133 a.a.        Molecular weight: 15326.56 Da        Isoelectric Point: 4.6345

>T54047 WP_002791882.1 NZ_CP011339:4659010-4659408 [Microcystis panniformis FACHB-1757]
MNQYLAELSEYGSITLEDYRTLRERQLAIERLIQLIVQTGIDINYQILKCLDIESPNNARDALFQIVELGILEEHLAVQL
AESIKLRNLLVHLYKKIDPDIVHSSIANILRDYPRYQRSIVQYLDSLEAENG

Download         Length: 399 bp

>T54047 NZ_CP011339:4659010-4659408 [Microcystis panniformis FACHB-1757]
ATGAATCAATACCTCGCCGAACTTAGCGAGTACGGTTCGATCACCTTAGAGGATTATCGTACATTAAGAGAACGTCAATT
AGCCATAGAAAGGTTAATTCAGCTTATCGTTCAAACTGGCATCGATATCAATTACCAGATTTTAAAATGTTTAGATATCG
AGTCTCCGAATAATGCTCGCGACGCATTATTTCAAATCGTAGAACTGGGAATCTTAGAAGAACACCTAGCCGTTCAACTG
GCCGAGTCTATTAAATTAAGAAACTTACTCGTACACTTATACAAGAAAATTGATCCCGATATTGTTCATTCCTCGATCGC
TAATATTTTACGAGATTATCCTCGCTACCAACGCTCGATCGTTCAATATCTAGATTCCTTGGAGGCAGAAAATGGTTAA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13895.05 Da        Isoelectric Point: 7.1665

>AT54047 WP_284525888.1 NZ_CP011339:4659401-4659757 [Microcystis panniformis FACHB-1757]
MVKNTKELKIINTINRITTTVEKIPNLKLLILFGSRARREHKPDSDWDLAISYDEANRQTHIKEISNDYLTSLSILSELF
EINRDLIDLIELDRCSPLMKYQVARDGKLIYEKIRETF

Download         Length: 357 bp

>AT54047 NZ_CP011339:4659401-4659757 [Microcystis panniformis FACHB-1757]
ATGGTTAAAAATACGAAAGAATTGAAAATTATCAATACAATCAATAGAATAACCACGACTGTGGAAAAAATACCGAATTT
AAAACTATTAATTCTCTTCGGTTCTAGAGCGCGCAGAGAGCATAAACCTGATAGCGATTGGGATTTGGCAATTTCATACG
ATGAAGCAAACAGACAAACACATATTAAGGAAATCAGTAATGATTACTTAACTTCTCTCTCTATCTTGAGTGAATTGTTT
GAGATAAACCGTGATTTGATCGATCTAATTGAACTCGATCGCTGTTCTCCATTAATGAAGTATCAAGTCGCACGAGATGG
AAAACTTATCTATGAAAAAATACGGGAGACTTTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB I4HG17


Antitoxin

Source ID Structure

References