Detailed information of TA system TA054040

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 2459496..2459914
• Replicon: chromosome
• Accession: NZ_CP011339
• Organism: Microcystis panniformis FACHB-1757

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: VL20_RS11855
• Protein ID: WP_052276614.1
• Coordinates: 2459702..2459914 (-)
• Length: 71 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: VL20_RS11850
• Protein ID: WP_052276613.1
• Coordinates: 2459496..2459702 (-)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VL20_RS11795 (VL20_2868)	2454882..2455864	-	983	Protein_2463	DNA (cytosine-5-)-methyltransferase	-
VL20_RS11800 (VL20_2870)	2455911..2456159	-	249	WP_002789664.1	DUF4926 domain-containing protein	-
VL20_RS11805 (VL20_2871)	2456162..2456491	-	330	WP_002789666.1	hypothetical protein	-
VL20_RS11810 (VL20_2872)	2456524..2456778	-	255	WP_052276610.1	hypothetical protein	-
VL20_RS11815 (VL20_2873)	2456815..2457036	-	222	WP_002769518.1	DUF2283 domain-containing protein	-
VL20_RS11820 (VL20_2874)	2457130..2457342	-	213	WP_002789670.1	hypothetical protein	-
VL20_RS11825 (VL20_2875)	2457339..2457815	-	477	WP_002789671.1	type II toxin-antitoxin system VapC family toxin	-
VL20_RS11830 (VL20_2877)	2458327..2458563	-	237	WP_002743276.1	DUF4926 domain-containing protein	-
VL20_RS11835 (VL20_2878)	2458576..2458896	-	321	WP_052276611.1	hypothetical protein	-
VL20_RS11840 (VL20_2879)	2458946..2459140	-	195	WP_052276612.1	hypothetical protein	-
VL20_RS11845 (VL20_2880)	2459134..2459334	-	201	WP_002743272.1	hypothetical protein	-
VL20_RS11850 (VL20_2881)	2459496..2459702	-	207	WP_052276613.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
VL20_RS11855 (VL20_2882)	2459702..2459914	-	213	WP_052276614.1	type II toxin-antitoxin system HicA family toxin	Toxin
VL20_RS11860 (VL20_2883)	2459949..2461427	-	1479	WP_052276615.1	GUN4 domain-containing protein	-
VL20_RS11865 (VL20_2884)	2461855..2463966	-	2112	WP_052276616.1	TIGR00300 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2435448..2459914	24466

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-62)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 8114.32 Da
• Isoelectric Point: 10.5371

>T54040 WP_052276614.1 NZ_CP011339:c2459914-2459702 [Microcystis panniformis FACHB-1757]
MKVRDVIRLLEQDGWYLSRTRGSHRQFKHSLKSGLVTIPGKLSDDLAIKTLRSIFKQAQLNKYLEEGDNN

Nucleotide

• Length: 213 bp

>T54040 NZ_CP011339:c2459914-2459702 [Microcystis panniformis FACHB-1757]
ATGAAAGTTAGAGATGTAATTAGATTACTAGAACAAGATGGATGGTATTTATCGAGAACAAGGGGAAGCCACCGACAATT
CAAACATTCTCTGAAATCAGGTTTAGTTACTATTCCGGGTAAGCTGTCCGATGATTTAGCGATTAAGACTTTACGGAGTA
TTTTCAAACAAGCTCAATTGAATAAATATCTAGAAGAAGGAGACAATAACTAA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7664.67 Da
• Isoelectric Point: 3.9642

>AT54040 WP_052276613.1 NZ_CP011339:c2459702-2459496 [Microcystis panniformis FACHB-1757]
MRYAIIIEKAENNYSAYVPDLPGCVTTGKTLEEITENMKEAIQFHLDGLQEEGLPIPQPATYCEYIEA

Nucleotide

• Length: 207 bp

>AT54040 NZ_CP011339:c2459702-2459496 [Microcystis panniformis FACHB-1757]
ATGCGTTACGCGATTATTATCGAAAAAGCTGAAAATAACTATTCCGCTTATGTTCCTGATTTACCCGGTTGTGTTACTAC
AGGTAAAACCCTAGAGGAAATCACAGAAAATATGAAAGAAGCAATTCAATTTCATCTGGATGGATTACAAGAGGAAGGGC
TGCCAATTCCCCAACCAGCCACCTATTGCGAGTATATCGAAGCGTAA