Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2450275..2451093 | Replicon | chromosome |
| Accession | NZ_CP011331 | ||
| Organism | Escherichia coli O104:H4 str. C227-11 isolate 368 shch | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A0E0Y102 |
| Locus tag | AAF13_RS12525 | Protein ID | WP_000771609.1 |
| Coordinates | 2450275..2450649 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0E0Y470 |
| Locus tag | AAF13_RS12530 | Protein ID | WP_001285568.1 |
| Coordinates | 2450740..2451093 (-) | Length | 118 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AAF13_RS12485 | 2445279..2445770 | - | 492 | WP_001297187.1 | DUF1097 domain-containing protein | - |
| AAF13_RS12490 | 2445872..2446426 | - | 555 | WP_001001902.1 | molecular chaperone YcdY | - |
| AAF13_RS12495 | 2446450..2447187 | - | 738 | WP_000283664.1 | zinc-binding phosphatase | - |
| AAF13_RS12500 | 2447242..2448180 | - | 939 | WP_000351313.1 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| AAF13_RS12510 | 2448651..2449493 | - | 843 | WP_001274560.1 | DUF4942 domain-containing protein | - |
| AAF13_RS12515 | 2449578..2449775 | - | 198 | WP_000839270.1 | DUF957 domain-containing protein | - |
| AAF13_RS12520 | 2449787..2450278 | - | 492 | WP_000976860.1 | hypothetical protein | - |
| AAF13_RS12525 | 2450275..2450649 | - | 375 | WP_000771609.1 | TA system toxin CbtA family protein | Toxin |
| AAF13_RS12530 | 2450740..2451093 | - | 354 | WP_001285568.1 | type IV toxin-antitoxin system toxin CbtA | Antitoxin |
| AAF13_RS12535 | 2451169..2451390 | - | 222 | WP_000692357.1 | DUF987 domain-containing protein | - |
| AAF13_RS12540 | 2451453..2451929 | - | 477 | WP_001186756.1 | RadC family protein | - |
| AAF13_RS12545 | 2451945..2452418 | - | 474 | WP_000855049.1 | antirestriction protein | - |
| AAF13_RS12550 | 2452512..2452757 | - | 246 | WP_001164966.1 | hypothetical protein | - |
| AAF13_RS12555 | 2452757..2453578 | - | 822 | WP_001241709.1 | DUF945 domain-containing protein | - |
| AAF13_RS12560 | 2453799..2454209 | - | 411 | WP_000846716.1 | hypothetical protein | - |
| AAF13_RS12565 | 2454225..2454908 | - | 684 | WP_000775510.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14006.09 Da Isoelectric Point: 7.2652
>T54020 WP_000771609.1 NZ_CP011331:c2450649-2450275 [Escherichia coli O104:H4 str. C227-11]
MKLLPDTHVREASCCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK
MKLLPDTHVREASCCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK
Download Length: 375 bp
>T54020 NZ_CP011331:c2450649-2450275 [Escherichia coli O104:H4 str. C227-11]
ATGAAATTATTACCCGACACACATGTACGGGAGGCATCATGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGTCTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA
ATGAAATTATTACCCGACACACATGTACGGGAGGCATCATGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGTCTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA
Antitoxin
Download Length: 118 a.a. Molecular weight: 13064.82 Da Isoelectric Point: 5.9541
>AT54020 WP_001285568.1 NZ_CP011331:c2451093-2450740 [Escherichia coli O104:H4 str. C227-11]
VSDTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPR
HQHTVTLYAKGLTCDADTLGSCGYVYLAVYPTPETKK
VSDTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPR
HQHTVTLYAKGLTCDADTLGSCGYVYLAVYPTPETKK
Download Length: 354 bp
>AT54020 NZ_CP011331:c2451093-2450740 [Escherichia coli O104:H4 str. C227-11]
GTGTCAGACACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGACGCCCTGTTTCGGCGC
CCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGTTCAGCGATGCAGATG
CGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGTGAACTGAATCCCCGC
CATCAGCATACCGTCACGCTATATGCTAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTGTGGTTACGTTTATCT
GGCTGTTTATCCGACCCCCGAAACGAAAAAGTAA
GTGTCAGACACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGACGCCCTGTTTCGGCGC
CCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGTTCAGCGATGCAGATG
CGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGTGAACTGAATCCCCGC
CATCAGCATACCGTCACGCTATATGCTAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTGTGGTTACGTTTATCT
GGCTGTTTATCCGACCCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0Y102 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0Y470 |