54004

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 142931..143504 Replicon chromosome
Accession NZ_CP011330
Organism Helicobacter pylori J99

Toxin (Protein)


Gene name relE Uniprot ID Q9ZKV4
Locus tag YH61_RS00615 Protein ID WP_001880357.1
Coordinates 143232..143504 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID M3K213
Locus tag YH61_RS00610 Protein ID WP_001134114.1
Coordinates 142931..143218 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YH61_RS08085 138789..139199 + 411 WP_010882572.1 hypothetical protein -
YH61_RS00605 140201..142435 + 2235 WP_046655432.1 Hop family adhesin BabA -
YH61_RS00610 142931..143218 + 288 WP_001134114.1 type II toxin-antitoxin system antitoxin Antitoxin
YH61_RS00615 143232..143504 + 273 WP_001880357.1 type II toxin-antitoxin system mRNA interferase toxin, HP0892 family Toxin
YH61_RS00620 143552..143803 + 252 WP_001134119.1 hypothetical protein -
YH61_RS08620 144167..144313 + 147 WP_000820666.1 hypothetical protein -
YH61_RS00625 144381..144587 + 207 WP_000917077.1 hypothetical protein -
YH61_RS08525 144709..144903 - 195 Protein_114 IS200/IS605 family transposase -
YH61_RS00635 144931..146259 + 1329 WP_000867414.1 transposase -
YH61_RS00640 146408..146710 + 303 WP_000889627.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
YH61_RS00645 146785..147309 - 525 WP_001135603.1 acyl-CoA thioesterase -
YH61_RS00650 147449..148306 + 858 WP_000538063.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 144931..146259 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10484.42 Da        Isoelectric Point: 9.7463

>T54004 WP_001880357.1 NZ_CP011330:143232-143504 [Helicobacter pylori J99]
MLTIETSKKFDKDLKILVKNGFDLKLLYKVVGNLATEQPLEPKYKDHPLKGALKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF

Download         Length: 273 bp

>T54004 NZ_CP011330:143232-143504 [Helicobacter pylori J99]
ATGCTGACGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAATGGGTTTGATTTAAAGCTTTT
GTATAAAGTGGTTGGAAATTTAGCCACAGAGCAACCCCTAGAACCCAAATACAAAGACCACCCACTCAAAGGCGCTTTAA
AAGACTTTAGGGAATGCCACCTAAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACAAGAAAACACTCTTTTTTTA
GTAAGGCTAGGCAGTCATAGCGAGCTGTTTTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11378.18 Da        Isoelectric Point: 10.4152

>AT54004 WP_001134114.1 NZ_CP011330:142931-143218 [Helicobacter pylori J99]
MPNTTNKDYTKYSQKQLFNFLNSIKAKQKRALEKLKEIQTQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNRL
CFKSIEDFKKHCENL

Download         Length: 288 bp

>AT54004 NZ_CP011330:142931-143218 [Helicobacter pylori J99]
ATGCCTAACACCACCAACAAAGACTACACAAAATACAGCCAAAAACAGCTTTTTAATTTTTTAAATTCTATCAAGGCAAA
GCAAAAAAGAGCGTTAGAAAAATTGAAAGAAATCCAAACTCAAAAGCAAAGGATTAAAAAAGCACTCCAATTTAAAGCGC
TCCATTTAACCGAAAATGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAGGACACTAAGAACCGCCTT
TGTTTTAAAAGCATAGAGGATTTTAAGAAGCATTGTGAAAACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1W0VLH9

Antitoxin

Source ID Structure
AlphaFold DB M3K213

References