Detailed information of TA system TA054001

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 238281..238893
• Replicon: chromosome
• Accession: NZ_CP011329
• Organism: Streptococcus agalactiae strain H002

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q8E7D3
• Locus tag: SAH002_RS01370
• Protein ID: WP_000384859.1
• Coordinates: 238281..238616 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: SAH002_RS01375
• Protein ID: WP_000259017.1
• Coordinates: 238606..238893 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAH002_RS01340	233479..234120	+	642	WP_000591145.1	hypothetical protein	-
SAH002_RS01350	234420..235295	+	876	WP_000421237.1	hypothetical protein	-
SAH002_RS01355	235331..235765	+	435	WP_001220482.1	hypothetical protein	-
SAH002_RS01360	236082..237338	+	1257	WP_000122836.1	plasmid recombination protein	-
SAH002_RS01365	237506..237976	+	471	WP_000130119.1	hypothetical protein	-
SAH002_RS01370	238281..238616	-	336	WP_000384859.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SAH002_RS01375	238606..238893	-	288	WP_000259017.1	hypothetical protein	Antitoxin
SAH002_RS01380	239400..239690	+	291	WP_000078283.1	WXG100 family type VII secretion target	-
SAH002_RS01385	239792..240199	+	408	WP_000749954.1	hypothetical protein	-
SAH002_RS01390	240199..240759	+	561	WP_001865562.1	hypothetical protein	-
SAH002_RS01395	240732..241412	+	681	WP_001865565.1	hypothetical protein	-
SAH002_RS01400	241397..241783	+	387	WP_000259069.1	hypothetical protein	-
SAH002_RS01405	241817..242098	+	282	WP_000052406.1	hypothetical protein	-
SAH002_RS01420	242941..243801	+	861	WP_000477654.1	Rgg/GadR/MutR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	230311..239167	8856

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13296.98 Da
• Isoelectric Point: 4.6565

>T54001 WP_000384859.1 NZ_CP011329:c238616-238281 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T54001 NZ_CP011329:c238616-238281 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGGGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT54001 WP_000259017.1 NZ_CP011329:c238893-238606 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT54001 NZ_CP011329:c238893-238606 [Streptococcus agalactiae]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6