53987

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3026510..3027164 Replicon chromosome
Accession NZ_CP011324
Organism Escherichia coli strain SQ2203

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag CS35_RS14995 Protein ID WP_000244777.1
Coordinates 3026510..3026917 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag CS35_RS15000 Protein ID WP_000354046.1
Coordinates 3026898..3027164 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CS35_RS14975 3022467..3024200 - 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -
CS35_RS14980 3024206..3024916 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CS35_RS14985 3024941..3025837 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
CS35_RS14990 3025949..3026470 + 522 WP_001055874.1 flavodoxin FldB -
CS35_RS14995 3026510..3026917 - 408 WP_000244777.1 toxin CptA Toxin
CS35_RS15000 3026898..3027164 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
CS35_RS15005 3027407..3028387 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
CS35_RS15010 3028583..3029242 - 660 WP_000250274.1 hemolysin III family protein -
CS35_RS15015 3029406..3029717 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
CS35_RS15020 3029762..3031195 + 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
CS35_RS15025 3031252..3031995 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T53987 WP_000244777.1 NZ_CP011324:c3026917-3026510 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T53987 NZ_CP011324:c3026917-3026510 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT53987 WP_000354046.1 NZ_CP011324:c3027164-3026898 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT53987 NZ_CP011324:c3027164-3026898 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References