Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1501773..1502411 Replicon chromosome
Accession NZ_CP011321
Organism Escherichia coli strain SQ88

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag SG49_RS07500 Protein ID WP_000813794.1
Coordinates 1501773..1501949 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag SG49_RS07505 Protein ID WP_001270286.1
Coordinates 1501995..1502411 (+) Length 139 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SG49_RS07480 1497392..1498606 - 1215 WP_001326689.1 BenE family transporter YdcO -
SG49_RS07485 1498659..1499195 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
SG49_RS07490 1499268..1501229 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
SG49_RS07495 1501321..1501551 - 231 WP_000494244.1 YncJ family protein -
SG49_RS07500 1501773..1501949 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
SG49_RS07505 1501995..1502411 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
SG49_RS07510 1502490..1503896 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
SG49_RS07515 1504141..1505286 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
SG49_RS07520 1505304..1506317 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
SG49_RS07525 1506318..1507259 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-57)

Antitoxin

(91-134)


Sequences


Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T53885 WP_000813794.1 NZ_CP011321:1501773-1501949 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T53885 NZ_CP011321:1501773-1501949 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT53885 WP_001270286.1 NZ_CP011321:1501995-1502411 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT53885 NZ_CP011321:1501995-1502411 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6HPB


Antitoxin

Source ID Structure

References