53858

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3037656..3038310 Replicon chromosome
Accession NZ_CP011320
Organism Escherichia coli strain SQ37

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag SG48_RS15050 Protein ID WP_000244777.1
Coordinates 3037656..3038063 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag SG48_RS15055 Protein ID WP_000354046.1
Coordinates 3038044..3038310 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SG48_RS15030 3033613..3035346 - 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -
SG48_RS15035 3035352..3036062 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
SG48_RS15040 3036087..3036983 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
SG48_RS15045 3037095..3037616 + 522 WP_001055874.1 flavodoxin FldB -
SG48_RS15050 3037656..3038063 - 408 WP_000244777.1 toxin CptA Toxin
SG48_RS15055 3038044..3038310 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
SG48_RS15060 3038553..3039533 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
SG48_RS15065 3039729..3040388 - 660 WP_000250274.1 hemolysin III family protein -
SG48_RS15070 3040552..3040863 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
SG48_RS15075 3040908..3042341 + 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
SG48_RS15080 3042398..3043141 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T53858 WP_000244777.1 NZ_CP011320:c3038063-3037656 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T53858 NZ_CP011320:c3038063-3037656 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT53858 WP_000354046.1 NZ_CP011320:c3038310-3038044 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT53858 NZ_CP011320:c3038310-3038044 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References