Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/StbC(antitoxin)
Location 5199851..5200482 Replicon chromosome
Accession NZ_CP011319
Organism Janthinobacterium sp. 1_2014MBL_MicDiv

Toxin (Protein)


Gene name vapC Uniprot ID A0A1I9Y241
Locus tag YQ44_RS22400 Protein ID WP_071325270.1
Coordinates 5199851..5200273 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1I9Y242
Locus tag YQ44_RS22405 Protein ID WP_071325271.1
Coordinates 5200273..5200482 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YQ44_RS22375 5195848..5197044 + 1197 WP_071325265.1 type II secretion system F family protein -
YQ44_RS22380 5197150..5198019 + 870 WP_071325266.1 A24 family peptidase -
YQ44_RS22385 5198062..5198709 + 648 WP_071325267.1 dephospho-CoA kinase -
YQ44_RS22390 5198772..5199527 + 756 WP_071325268.1 cell division protein ZapD -
YQ44_RS22395 5199539..5199727 + 189 WP_071325269.1 DNA gyrase inhibitor YacG -
YQ44_RS22400 5199851..5200273 - 423 WP_071325270.1 hypothetical protein Toxin
YQ44_RS22405 5200273..5200482 - 210 WP_071325271.1 hypothetical protein Antitoxin
YQ44_RS22410 5200603..5201040 - 438 WP_071325272.1 NUDIX domain-containing protein -
YQ44_RS22415 5201037..5201903 - 867 WP_071325273.1 ATP-binding protein -
YQ44_RS22420 5201900..5203138 - 1239 WP_071325274.1 bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ -
YQ44_RS28445 5203560..5204690 + 1131 WP_198043800.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14978.35 Da        Isoelectric Point: 6.2188

>T53827 WP_071325270.1 NZ_CP011319:c5200273-5199851 [Janthinobacterium sp. 1_2014MBL_MicDiv]
MPDPAYLLDTDVIVAARRGSAAPAGVGAFFERVAPAARYVPVQVIAQLRAGIQQSWRREAALEALALEAWLEALLVEYAP
RLLEFDLDCALVCARLHGRAHAHGVDGQIAAMGIAYGLTVVSGRLGSFVAQGLRLENPFI

Download         Length: 423 bp

>T53827 NZ_CP011319:c5200273-5199851 [Janthinobacterium sp. 1_2014MBL_MicDiv]
ATGCCTGATCCGGCTTATCTGCTGGATACGGACGTGATCGTTGCCGCGCGCCGCGGCAGCGCTGCGCCGGCGGGCGTGGG
CGCTTTTTTCGAACGCGTGGCGCCCGCGGCCCGCTATGTGCCGGTGCAGGTCATCGCGCAATTGCGCGCGGGCATACAGC
AAAGCTGGCGGCGCGAGGCGGCATTGGAAGCGCTGGCCCTGGAAGCGTGGCTGGAAGCGCTGCTGGTCGAGTATGCGCCG
CGCCTGCTCGAGTTCGACCTCGATTGCGCGCTCGTGTGCGCGCGCCTGCATGGCCGTGCCCATGCGCATGGCGTGGACGG
GCAGATCGCGGCGATGGGCATCGCCTATGGCTTGACGGTGGTCAGTGGCAGGCTCGGCAGTTTCGTGGCGCAGGGGCTGC
GCCTGGAAAATCCGTTTATCTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7970.17 Da        Isoelectric Point: 7.4058

>AT53827 WP_071325271.1 NZ_CP011319:c5200482-5200273 [Janthinobacterium sp. 1_2014MBL_MicDiv]
MALTLTFTDTDELLLAALHKRARAHGRSIEEEHRDILRHALRPLPKRPLEDILRSMPAVGLDTDFERRS

Download         Length: 210 bp

>AT53827 NZ_CP011319:c5200482-5200273 [Janthinobacterium sp. 1_2014MBL_MicDiv]
ATGGCGCTGACCCTGACCTTTACCGACACCGATGAATTGCTGCTGGCGGCGCTGCACAAGCGTGCCCGCGCGCATGGTCG
CAGCATCGAGGAAGAACACCGCGACATCCTGCGCCATGCCTTGCGTCCGCTGCCGAAGCGCCCGCTCGAGGATATCTTGC
GCAGCATGCCCGCAGTGGGGCTCGACACGGATTTCGAACGCCGCTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I9Y241

Antitoxin

Source ID Structure
AlphaFold DB A0A1I9Y242

References