Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5911327..5911941 Replicon chromosome
Accession NZ_CP011317
Organism Pseudomonas aeruginosa strain Carb01 63

Toxin (Protein)


Gene name hicA Uniprot ID A6VBH9
Locus tag YQ19_RS36760 Protein ID WP_071534354.1
Coordinates 5911759..5911941 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A140SDX7
Locus tag YQ19_RS28030 Protein ID WP_012077229.1
Coordinates 5911327..5911731 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YQ19_RS28005 5907467..5908177 + 711 WP_012074129.1 hypothetical protein -
YQ19_RS28010 5908174..5909094 + 921 WP_012074128.1 hypothetical protein -
YQ19_RS28015 5909091..5909630 + 540 WP_012074127.1 hypothetical protein -
YQ19_RS28020 5909630..5910328 + 699 WP_033896049.1 hypothetical protein -
YQ19_RS28025 5910313..5911284 + 972 WP_012077228.1 hypothetical protein -
YQ19_RS28030 5911327..5911731 - 405 WP_012077229.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
YQ19_RS36760 5911759..5911941 - 183 WP_071534354.1 type II toxin-antitoxin system HicA family toxin Toxin
YQ19_RS28035 5912484..5913416 - 933 WP_003120918.1 ZIP family metal transporter -
YQ19_RS28040 5913435..5914046 - 612 WP_003098862.1 superoxide dismutase -
YQ19_RS28045 5914059..5914508 - 450 WP_003094369.1 hypothetical protein -
YQ19_RS28050 5914536..5915912 - 1377 WP_003098863.1 class II fumarate hydratase -
YQ19_RS28055 5915905..5916300 - 396 WP_003162782.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5874447..5911941 37494


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6702.74 Da        Isoelectric Point: 10.4826

>T53825 WP_071534354.1 NZ_CP011317:c5911941-5911759 [Pseudomonas aeruginosa]
MRSREVIDLLLEDGWYEVAVKGSHHQFKHPSKPGKVTVQHPSSTIPKGTLNNILKQAGLK

Download         Length: 183 bp

>T53825 NZ_CP011317:c5911941-5911759 [Pseudomonas aeruginosa]
ATGCGGAGTAGGGAAGTGATTGATTTGCTGTTGGAGGATGGCTGGTATGAAGTGGCGGTGAAAGGTAGCCACCACCAGTT
CAAACATCCTTCAAAGCCTGGAAAGGTGACGGTTCAACATCCGTCCTCGACGATACCGAAAGGAACCCTGAACAACATAC
TGAAACAAGCCGGCCTCAAGTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14670.54 Da        Isoelectric Point: 4.4315

>AT53825 WP_012077229.1 NZ_CP011317:c5911731-5911327 [Pseudomonas aeruginosa]
MKFPVVLHKDPDSDYGVTVPDVPGCFSAGATVSEALANVEEALALHFEGLVTDGEELPQPQDVDAHMKNPDFEGGVWAVV
DFDVTPYLGKAVRFNATLPEHLLQRIDERVKVDKRYQSRSGFLATAAMRELSVA

Download         Length: 405 bp

>AT53825 NZ_CP011317:c5911731-5911327 [Pseudomonas aeruginosa]
ATGAAATTCCCCGTGGTGTTACACAAAGACCCTGATTCTGACTATGGCGTGACTGTGCCCGATGTGCCGGGTTGCTTCTC
TGCCGGCGCTACGGTGTCCGAGGCCCTGGCCAATGTAGAAGAGGCGCTGGCCTTGCACTTCGAAGGCTTGGTTACGGACG
GCGAAGAGCTACCCCAGCCGCAGGACGTTGACGCCCATATGAAGAATCCGGACTTCGAAGGTGGCGTATGGGCGGTGGTT
GACTTCGACGTGACCCCGTACCTGGGCAAGGCCGTACGCTTTAATGCGACGCTCCCGGAACACCTTCTGCAGCGGATCGA
TGAGCGCGTGAAGGTGGATAAGCGCTATCAGTCTCGGTCGGGCTTTCTGGCAACAGCGGCGATGCGCGAACTGTCAGTGG
CGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6VBH9

Antitoxin

Source ID Structure
AlphaFold DB A0A140SDX7

References