Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2933724..2934240 Replicon chromosome
Accession NZ_CP011317
Organism Pseudomonas aeruginosa strain Carb01 63

Toxin (Protein)


Gene name relE Uniprot ID A0A3R8UIH5
Locus tag YQ19_RS14310 Protein ID WP_025297453.1
Coordinates 2933959..2934240 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8UIM7
Locus tag YQ19_RS14305 Protein ID WP_025297454.1
Coordinates 2933724..2933969 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YQ19_RS36145 2928846..2929175 - 330 WP_031692728.1 hypothetical protein -
YQ19_RS36150 2929523..2930191 + 669 WP_071534660.1 hypothetical protein -
YQ19_RS14295 2930188..2931294 + 1107 WP_025297456.1 XRE family transcriptional regulator -
YQ19_RS14300 2931425..2933566 + 2142 WP_025297455.1 hypothetical protein -
YQ19_RS14305 2933724..2933969 + 246 WP_025297454.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
YQ19_RS14310 2933959..2934240 + 282 WP_025297453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
YQ19_RS14315 2934646..2935227 - 582 WP_033895412.1 plasmid pRiA4b ORF-3 family protein -
YQ19_RS14320 2935241..2936116 - 876 WP_033895413.1 WYL domain-containing protein -
YQ19_RS14325 2936251..2937825 + 1575 WP_025297452.1 DNA recombination protein RmuC -
YQ19_RS14330 2937849..2938497 + 649 Protein_2891 peptidase M15 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2909224..2984837 75613


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10824.61 Da        Isoelectric Point: 10.6249

>T53822 WP_025297453.1 NZ_CP011317:2933959-2934240 [Pseudomonas aeruginosa]
MTYELEFLPSALKEWQKLGHTVREQIKKKLRERLDNPKVQADALRDMPGHYKIKLRASGYRLVYRVEDERVVVVVVAVGK
RERGAAYQSAKGR

Download         Length: 282 bp

>T53822 NZ_CP011317:2933959-2934240 [Pseudomonas aeruginosa]
ATGACCTATGAGCTGGAGTTCCTGCCCTCAGCCCTGAAGGAGTGGCAGAAGCTCGGCCATACGGTGCGCGAGCAGATCAA
AAAGAAACTGCGCGAGCGCCTGGATAATCCCAAGGTTCAGGCCGACGCCCTCAGGGATATGCCGGGGCACTACAAAATCA
AGCTGCGTGCATCGGGCTATCGTCTGGTATACCGCGTCGAAGATGAGCGCGTGGTGGTCGTGGTGGTTGCCGTTGGCAAG
CGCGAGCGTGGGGCCGCTTACCAATCTGCCAAGGGCCGTTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8797.21 Da        Isoelectric Point: 4.2550

>AT53822 WP_025297454.1 NZ_CP011317:2933724-2933969 [Pseudomonas aeruginosa]
MQSILADVAVSVSELKKNPSGILAGAGGMPVAVLNHNRVMGYMVPAELYEQMMERLDDLELVEIVKARSGEESVPVRLDD
L

Download         Length: 246 bp

>AT53822 NZ_CP011317:2933724-2933969 [Pseudomonas aeruginosa]
ATGCAGAGTATCTTGGCTGACGTCGCTGTCAGCGTTTCTGAGTTGAAGAAAAATCCGTCGGGCATCCTGGCTGGTGCAGG
TGGTATGCCTGTCGCCGTGCTCAACCACAATCGCGTCATGGGATACATGGTGCCGGCAGAGCTCTATGAGCAGATGATGG
AGCGCCTAGATGATCTGGAGTTGGTCGAAATAGTGAAGGCTCGCTCGGGCGAGGAGTCTGTCCCGGTGCGTTTGGATGAC
CTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8UIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8UIM7

References