Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2763232..2764757 Replicon chromosome
Accession NZ_CP011310
Organism Aurantiacibacter atlanticus strain s21-N3

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag CP97_RS13500 Protein ID WP_048886374.1
Coordinates 2763232..2764503 (-) Length 424 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag CP97_RS13505 Protein ID WP_048886375.1
Coordinates 2764500..2764757 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP97_RS13495 2759984..2763103 - 3120 WP_149036489.1 DEAD/DEAH box helicase family protein -
CP97_RS13500 2763232..2764503 - 1272 WP_048886374.1 type II toxin-antitoxin system HipA family toxin Toxin
CP97_RS13505 2764500..2764757 - 258 WP_048886375.1 helix-turn-helix transcriptional regulator Antitoxin
CP97_RS13510 2765177..2765392 - 216 WP_048886376.1 hypothetical protein -
CP97_RS13515 2765556..2766224 - 669 WP_048886377.1 OmpW family protein -
CP97_RS13520 2766462..2767775 + 1314 WP_174539184.1 oxygen-independent coproporphyrinogen III oxidase -
CP97_RS13525 2768155..2768445 - 291 WP_063612450.1 hypothetical protein -
CP97_RS13530 2768593..2769141 - 549 WP_048886380.1 DUF389 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2744192..2798826 54634


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(152-385)

Antitoxin

Transcription regulator, HipB-like

(6-62)


Sequences

Toxin        


Download         Length: 424 a.a.        Molecular weight: 45876.20 Da        Isoelectric Point: 4.9174

>T53817 WP_048886374.1 NZ_CP011310:c2764503-2763232 [Aurantiacibacter atlanticus]
VTLPILDTLVVWWDDRQAGELSIDKGGAMHFAYAPEWQADETAPALSHAMPKQQKPFRDHACKAVFGGLLPEESQRTAIA
RALGVSPDNPFRLLEALGGDVAGALAFLPKDEEPLHDHSETTPEPLQENELAELLDRLPAVPMLAGEGGARLSLAGAQSK
LPVLLTADGGIAIPRPGEPSTHLIKPEPDRFAGLAANEAFCLALARAVGIDAAHAEWREVAGKPLLLVERYDRMSVEGKT
KRLHQEDFAQALSVPSNRKYAAEGGPTFRDSFALLRSAATRPAREVLKLAEAAIFNLIIGNADAHAKNYSLLRRENGEVV
LAPLYDLVATHMWEELSPKLAMRFGRAATLDEFDRESVARFADEVVLGAPYIRRRVSDLARAVTEEIEQGVQVPGNPPED
AVATIAEALSARAKVLSIKLFED

Download         Length: 1272 bp

>T53817 NZ_CP011310:c2764503-2763232 [Aurantiacibacter atlanticus]
GTGACGCTGCCAATTCTGGATACGCTGGTGGTCTGGTGGGACGATCGCCAGGCAGGCGAACTCTCGATCGACAAAGGTGG
CGCGATGCATTTCGCATATGCACCTGAATGGCAGGCTGATGAAACGGCCCCGGCGCTTTCCCATGCGATGCCCAAGCAGC
AAAAGCCATTTAGAGACCATGCCTGCAAGGCTGTCTTTGGCGGACTGCTACCCGAGGAAAGCCAGCGTACGGCTATCGCT
CGCGCGCTTGGAGTTTCGCCCGACAATCCGTTTCGGCTGCTTGAGGCCTTGGGCGGAGATGTTGCCGGTGCTCTAGCCTT
CCTGCCCAAAGACGAAGAACCGCTCCACGACCACTCCGAGACCACTCCAGAACCACTCCAAGAGAACGAGCTGGCCGAAT
TGCTGGACAGACTGCCTGCTGTGCCCATGCTAGCAGGCGAGGGCGGCGCAAGGCTTAGCCTTGCAGGGGCACAGAGCAAG
CTGCCGGTGCTGCTCACTGCGGACGGTGGAATTGCTATCCCTCGTCCTGGAGAACCATCCACGCATCTGATCAAGCCTGA
ACCGGATCGCTTTGCCGGATTGGCTGCAAATGAGGCCTTCTGCCTCGCACTGGCGCGCGCCGTGGGCATTGATGCTGCCC
ACGCAGAGTGGCGCGAGGTGGCGGGCAAGCCGTTGCTGCTGGTCGAACGCTATGACCGGATGTCGGTCGAGGGAAAAACG
AAACGCCTGCATCAGGAAGACTTTGCTCAGGCACTTAGCGTCCCCTCAAACCGCAAATACGCGGCGGAGGGTGGGCCGAC
TTTCCGCGATAGCTTCGCGCTGTTACGCAGCGCTGCGACGCGGCCAGCACGCGAAGTGCTGAAGCTCGCCGAAGCCGCGA
TCTTCAATCTCATCATCGGCAACGCCGATGCCCACGCGAAGAATTACAGTCTGCTGCGCCGGGAGAACGGCGAGGTGGTG
CTTGCCCCGCTCTACGATCTCGTTGCCACGCATATGTGGGAAGAGCTCTCCCCCAAGCTCGCAATGCGTTTTGGCCGCGC
GGCGACCCTCGATGAATTTGACAGGGAAAGCGTGGCGAGGTTCGCGGACGAGGTAGTGCTAGGCGCCCCATACATTCGCC
GTCGAGTAAGTGACCTTGCTAGAGCGGTGACGGAGGAGATTGAGCAGGGAGTTCAGGTGCCCGGCAATCCGCCTGAGGAT
GCTGTCGCGACAATTGCCGAAGCATTATCGGCCCGCGCTAAAGTGCTCAGCATAAAACTCTTCGAAGATTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9110.71 Da        Isoelectric Point: 6.3200

>AT53817 WP_048886375.1 NZ_CP011310:c2764757-2764500 [Aurantiacibacter atlanticus]
MLDVAAIGQIIREERKELGLRQDALAAASGVGLRFLVELERGKPTVQMGKVLDVISALGCELQIKRPDGIVMAGRAVAPK
KDEAE

Download         Length: 258 bp

>AT53817 NZ_CP011310:c2764757-2764500 [Aurantiacibacter atlanticus]
ATGCTCGATGTTGCCGCTATCGGCCAAATCATTCGCGAAGAACGCAAGGAGCTTGGTCTGCGACAGGACGCGTTGGCCGC
TGCAAGCGGCGTCGGTTTGCGCTTCCTCGTCGAATTGGAGCGGGGGAAGCCCACTGTCCAGATGGGCAAGGTTCTTGATG
TGATTTCAGCACTGGGATGTGAATTGCAAATCAAGCGGCCTGACGGGATCGTGATGGCGGGTAGAGCGGTCGCGCCCAAG
AAGGATGAGGCGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References