Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 2790751..2791316 Replicon chromosome
Accession NZ_CP011307
Organism Intestinimonas butyriciproducens strain AF211

Toxin (Protein)


Gene name relE Uniprot ID A0A0S2W760
Locus tag IB211_RS13170 Protein ID WP_058118370.1
Coordinates 2790751..2791041 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0S2W752
Locus tag IB211_RS13175 Protein ID WP_022180030.1
Coordinates 2791038..2791316 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IB211_RS13160 2789313..2789993 - 681 WP_201015190.1 TetR/AcrR family transcriptional regulator -
IB211_RS13165 2790248..2790709 + 462 WP_147586197.1 hypothetical protein -
IB211_RS13170 2790751..2791041 - 291 WP_058118370.1 type II toxin-antitoxin system YafQ family toxin Toxin
IB211_RS13175 2791038..2791316 - 279 WP_022180030.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IB211_RS13180 2791840..2792568 + 729 WP_058118371.1 replication initiator protein A -
IB211_RS13185 2792565..2793416 + 852 WP_058118372.1 ATP-binding protein -
IB211_RS13190 2793413..2793607 + 195 WP_058118373.1 transposon-encoded TnpW family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(W) groEL 2645053..2911687 266634


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(7-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-70)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10978.72 Da        Isoelectric Point: 9.6560

>T53815 WP_058118370.1 NZ_CP011307:c2791041-2790751 [Intestinimonas butyriciproducens]
VRKTKLTVKPTTAFKKDYKLAIKRGLQIELLETVIETLAMGNALPPENRDHDLTGNWRGHRECHIQPGWLLIYRVEDDVL
VLTLSRTGTHSDLFGK

Download         Length: 291 bp

>T53815 NZ_CP011307:c2791041-2790751 [Intestinimonas butyriciproducens]
GTGAGAAAAACAAAGCTGACTGTCAAGCCGACCACGGCGTTCAAGAAGGATTACAAACTGGCAATCAAGCGCGGACTGCA
AATTGAGCTTCTTGAAACCGTGATCGAAACGCTTGCAATGGGAAACGCGCTGCCGCCTGAGAACAGAGATCATGACCTGA
CCGGCAACTGGCGTGGACACCGGGAGTGCCACATTCAGCCCGGCTGGCTTCTGATCTACCGCGTTGAGGACGATGTTCTG
GTGCTGACGCTTTCCAGAACCGGAACGCATAGCGATCTGTTCGGGAAATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10152.56 Da        Isoelectric Point: 4.4230

>AT53815 WP_022180030.1 NZ_CP011307:c2791316-2791038 [Intestinimonas butyriciproducens]
MAGTTTNISIRMDSDLKAQADALFSELGMNLTTAFNIFVRQSIREGGIPFEISINQPNKETIAAMLEAERIAKDPSVKGY
NDLDELFADLKK

Download         Length: 279 bp

>AT53815 NZ_CP011307:c2791316-2791038 [Intestinimonas butyriciproducens]
ATGGCTGGAACTACAACAAACATCAGCATCCGAATGGACAGCGACCTGAAAGCACAGGCTGACGCTTTGTTTTCGGAGCT
TGGCATGAATCTCACAACGGCTTTCAATATTTTCGTGCGTCAATCGATCCGGGAGGGCGGGATTCCGTTTGAAATCTCCA
TCAATCAGCCTAACAAGGAGACGATTGCCGCCATGCTGGAAGCGGAAAGGATTGCGAAAGACCCGTCTGTAAAGGGCTAT
AACGACCTTGACGAGCTTTTTGCCGATCTGAAAAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S2W760

Antitoxin

Source ID Structure
AlphaFold DB A0A0S2W752

References