Detailed information of TA system TA053814

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/upstrm_HI1419-dnstrm_HI1420
• Location: 266125..266773
• Replicon: chromosome
• Accession: NZ_CP011306
• Organism: Stenotrophomonas maltophilia strain ISMMS2R

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: A0A0L8AET4
• Locus tag: YH68_RS01160
• Protein ID: WP_010486984.1
• Coordinates: 266125..266412 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: YH68_RS01165
• Protein ID: WP_053442379.1
• Coordinates: 266471..266773 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YH68_RS01130	262099..262887	-	789	WP_029380115.1	zinc-dependent peptidase	-
YH68_RS01135	262854..263132	-	279	WP_010486993.1	hypothetical protein	-
YH68_RS01140	263276..264244	+	969	WP_053442377.1	bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA	-
YH68_RS01145	264241..264972	+	732	WP_049454338.1	type III pantothenate kinase	-
YH68_RS01150	264982..265830	+	849	WP_053442378.1	SPOR domain-containing protein	-
YH68_RS01160	266125..266412	+	288	WP_010486984.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
YH68_RS01165	266471..266773	+	303	WP_053442379.1	putative addiction module antidote protein	Antitoxin
YH68_RS01170	266831..267154	-	324	WP_053442380.1	hypothetical protein	-
YH68_RS01175	267235..267642	-	408	WP_053442381.1	hypothetical protein	-
YH68_RS01180	268237..269007	+	771	WP_053442382.1	DUF3011 domain-containing protein	-
YH68_RS01185	269032..269379	-	348	WP_053442383.1	hypothetical protein	-
YH68_RS01190	269512..270432	+	921	WP_049435516.1	arginase	-
YH68_RS01195	270595..270732	+	138	WP_008266021.1	entericidin A/B family lipoprotein	-
YH68_RS01200	270935..271156	+	222	WP_004137109.1	CsbD family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-90)

Antitoxin

• Cro/C1-type helix-turn-helix domain (43-95)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10744.34 Da
• Isoelectric Point: 10.8940

>T53814 WP_010486984.1 NZ_CP011306:266125-266412 [Stenotrophomonas maltophilia]
MKIQRTRQFATWIDALKDVTARARILARIGRLAEGHPGDHRYLADGVSELRIDAGPGYRVYYTQRGRQLVILLVGGDKGS
QQRDIEKAREIARAL

Nucleotide

• Length: 288 bp

>T53814 NZ_CP011306:266125-266412 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCACGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCGCTGAAGGCCATCCTGGTGATCACCGCTATCTGGCGGATGGCGTTTCTGAACTACGCATCGATG
CAGGACCGGGTTACCGCGTGTACTACACCCAGCGGGGCAGGCAGTTGGTGATTCTTCTGGTCGGAGGCGACAAGGGTTCG
CAACAGCGCGATATAGAGAAGGCCAGGGAGATTGCGCGTGCCCTGTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10705.33 Da
• Isoelectric Point: 7.1665

>AT53814 WP_053442379.1 NZ_CP011306:266471-266773 [Stenotrophomonas maltophilia]
MAIKKKVELEAFDVAEHLRTPEEMAAYLDACIEESDGDSAFIAKALGDIARAQGMSKVARAAGLSRVSLYRALSGERSPD
FATILKVTRALGVRLHASAV

Nucleotide

• Length: 303 bp

>AT53814 NZ_CP011306:266471-266773 [Stenotrophomonas maltophilia]
ATGGCTATCAAGAAGAAAGTTGAACTCGAAGCATTTGATGTGGCCGAGCACCTTCGTACACCCGAAGAAATGGCCGCCTA
TCTCGATGCCTGTATCGAGGAAAGCGATGGCGATTCTGCCTTCATCGCCAAGGCGCTGGGCGATATCGCCCGCGCTCAGG
GCATGAGCAAGGTTGCACGTGCGGCGGGCCTGTCGCGTGTGAGTCTGTATCGCGCCCTGTCCGGCGAGCGCAGCCCGGAT
TTCGCGACGATCCTGAAGGTGACCCGTGCCCTTGGTGTGCGCCTGCATGCCAGCGCCGTGTGA

Structures

Toxin

• AlphaFold DB: A0A0L8AET4