Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 1638311..1638901 Replicon chromosome
Accession NZ_CP011304
Organism Microcystis aeruginosa NIES-2549

Toxin (Protein)


Gene name PumA Uniprot ID A0A0F6RKM7
Locus tag myaer_RS07850 Protein ID WP_046661678.1
Coordinates 1638611..1638901 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID I4ID81
Locus tag myaer_RS07845 Protein ID WP_002757266.1
Coordinates 1638311..1638601 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
myaer_RS07820 1634245..1635843 - 1599 WP_046661674.1 carboxylate--amine ligase -
myaer_RS07825 1636009..1636137 - 129 WP_002738148.1 photosystem I reaction center subunit IX -
myaer_RS07830 1636183..1636677 - 495 WP_002748906.1 photosystem I reaction center subunit III -
myaer_RS07835 1636810..1637229 - 420 WP_002757262.1 secondary thiamine-phosphate synthase enzyme YjbQ -
myaer_RS07840 1637240..1638040 - 801 WP_046661676.1 uroporphyrinogen-III C-methyltransferase -
myaer_RS07845 1638311..1638601 - 291 WP_002757266.1 putative addiction module antidote protein Antitoxin
myaer_RS07850 1638611..1638901 - 291 WP_046661678.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
myaer_RS07855 1639079..1639885 - 807 WP_052734169.1 matrixin family metalloprotease -
myaer_RS07860 1640096..1640584 + 489 WP_046661680.1 hypothetical protein -
myaer_RS07865 1640730..1641020 + 291 WP_002757283.1 nucleotidyltransferase -
myaer_RS07870 1641010..1641360 + 351 WP_046661681.1 DUF86 domain-containing protein -
myaer_RS07875 1641741..1642640 + 900 WP_046661682.1 agmatinase -
myaer_RS07885 1642822..1643871 + 1050 WP_046661683.1 aromatic ring-hydroxylating dioxygenase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(7-92)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11054.65 Da        Isoelectric Point: 10.1314

>T53805 WP_046661678.1 NZ_CP011304:c1638901-1638611 [Microcystis aeruginosa NIES-2549]
MIEIRQTETYSQWFSNLRDRQAKARIDIRVRRLSMGNPGDVKPVGKGVSELRIDYGQGYRVYFIQRGETLIILLAAGDKQ
TQERDIKTALNLAQDL

Download         Length: 291 bp

>T53805 NZ_CP011304:c1638901-1638611 [Microcystis aeruginosa NIES-2549]
ATGATTGAAATTCGCCAGACCGAAACCTACTCTCAGTGGTTTAGCAATTTGCGGGATCGCCAAGCAAAAGCACGTATAGA
CATTCGTGTTCGTCGCCTGTCTATGGGCAATCCAGGCGATGTTAAACCAGTAGGAAAAGGTGTATCGGAACTGCGGATCG
ATTATGGCCAAGGCTATCGGGTGTATTTCATTCAGCGAGGAGAGACCTTGATCATCCTCTTGGCAGCAGGAGATAAGCAA
ACTCAAGAACGGGACATCAAAACAGCATTAAATTTAGCACAAGACTTATAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10320.80 Da        Isoelectric Point: 4.4475

>AT53805 WP_002757266.1 NZ_CP011304:c1638601-1638311 [Microcystis aeruginosa NIES-2549]
MATIQTYPWDAAEHLETKEDIAAYLEAALEDGDPSLVVAALGDIARSKGMTHIARETGLGRESLYKALSIEGNPEFATVL
KVLQSLGLRLQVVPIA

Download         Length: 291 bp

>AT53805 NZ_CP011304:c1638601-1638311 [Microcystis aeruginosa NIES-2549]
ATGGCTACTATCCAAACCTATCCTTGGGATGCGGCAGAACATCTCGAAACAAAAGAAGATATAGCTGCATATCTTGAAGC
AGCTCTTGAAGATGGCGATCCAAGCTTAGTGGTAGCAGCATTAGGTGATATTGCTCGATCTAAAGGGATGACACATATTG
CCCGTGAAACAGGGTTGGGGCGTGAAAGTCTCTATAAAGCTTTGTCAATCGAAGGCAATCCAGAGTTTGCCACAGTTCTT
AAGGTCTTACAATCACTTGGGTTACGCCTCCAAGTCGTACCAATTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6RKM7

Antitoxin

Source ID Structure
AlphaFold DB I4ID81

References