53804

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 4563620..4564200 Replicon chromosome
Accession NZ_CP011303
Organism Serratia liquefaciens strain HUMV-21

Toxin (Protein)


Gene name relE Uniprot ID A0A515D1D0
Locus tag XJ20_RS21280 Protein ID WP_046374632.1
Coordinates 4563620..4563904 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7W4F292
Locus tag XJ20_RS21285 Protein ID WP_020824985.1
Coordinates 4563913..4564200 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XJ20_RS21260 4559026..4559550 - 525 WP_046374629.1 NAD(P)H-dependent oxidoreductase -
XJ20_RS21265 4559655..4560563 + 909 WP_020824989.1 LysR family transcriptional regulator -
XJ20_RS21270 4560847..4562985 + 2139 WP_046374630.1 anaerobic ribonucleoside-triphosphate reductase -
XJ20_RS21275 4563159..4563623 + 465 WP_046374631.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
XJ20_RS21280 4563620..4563904 - 285 WP_046374632.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
XJ20_RS21285 4563913..4564200 - 288 WP_020824985.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
XJ20_RS21290 4564305..4565363 - 1059 WP_046374633.1 permease -
XJ20_RS21295 4565625..4566350 + 726 WP_170868571.1 phosphonate metabolism transcriptional regulator PhnF -
XJ20_RS21300 4566351..4566794 + 444 WP_046374634.1 phosphonate C-P lyase system protein PhnG -
XJ20_RS21305 4566797..4567378 + 582 WP_046374635.1 phosphonate C-P lyase system protein PhnH -
XJ20_RS21310 4567378..4568463 + 1086 WP_046374636.1 carbon-phosphorus lyase complex subunit PhnI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-44)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11173.88 Da        Isoelectric Point: 4.7160

>T53804 WP_046374632.1 NZ_CP011303:c4563904-4563620 [Serratia liquefaciens]
MRVEWDEEALRDRERIFDFLYPFNPQVAEQADAEIDKAVKRLLDYPELGKIWYRQARKLLVSQASLIVLYVVVDDVIKVL
AVVHQREKFPDIEN

Download         Length: 285 bp

>T53804 NZ_CP011303:c4563904-4563620 [Serratia liquefaciens]
ATGCGTGTCGAATGGGATGAAGAAGCGCTACGGGACAGGGAACGTATTTTTGATTTTCTCTATCCTTTTAATCCACAGGT
TGCTGAGCAGGCTGATGCTGAGATTGATAAGGCAGTGAAGCGCCTGTTGGATTACCCTGAACTCGGTAAAATTTGGTACA
GGCAGGCGCGTAAGTTATTGGTCAGCCAGGCTTCATTAATAGTTTTATACGTTGTTGTCGACGACGTGATTAAGGTTTTA
GCCGTTGTTCATCAACGAGAGAAATTCCCCGACATAGAGAACTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11043.40 Da        Isoelectric Point: 6.4766

>AT53804 WP_020824985.1 NZ_CP011303:c4564200-4563913 [Serratia liquefaciens]
MESRIQFRIEDETKRLAQKAAEAKGITLSEACRRLAEQMADEQRATEQHENWLKEKVDAAFARLHEGSAVYLDQQQVDES
MDAFKAKVRAKYDRK

Download         Length: 288 bp

>AT53804 NZ_CP011303:c4564200-4563913 [Serratia liquefaciens]
ATGGAAAGCCGTATCCAGTTTCGCATTGAGGATGAGACTAAACGTTTGGCGCAGAAAGCCGCAGAAGCCAAGGGGATCAC
TTTGAGTGAGGCGTGTCGACGTTTGGCTGAGCAAATGGCGGATGAGCAACGGGCCACTGAGCAACATGAAAATTGGTTGA
AAGAAAAGGTTGATGCCGCTTTTGCCCGTTTGCATGAAGGAAGTGCGGTCTATCTTGACCAGCAACAGGTTGATGAAAGC
ATGGATGCCTTTAAGGCAAAAGTCCGAGCGAAATACGACCGAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A515D1D0

Antitoxin

Source ID Structure
AlphaFold DB A0A7W4F292

References