Detailed information of TA system TA053802

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3927907..3928534
• Replicon: chromosome
• Accession: NZ_CP011303
• Organism: Serratia liquefaciens strain HUMV-21

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: -
• Locus tag: XJ20_RS18415
• Protein ID: WP_197821222.1
• Coordinates: 3928313..3928534 (+)
• Length: 74 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: A0A379ZYL8
• Locus tag: XJ20_RS18410
• Protein ID: WP_020825515.1
• Coordinates: 3927907..3928275 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XJ20_RS18380	3923955..3924209	+	255	WP_046374339.1	type B 50S ribosomal protein L31	-
XJ20_RS18385	3924222..3924362	+	141	WP_012005563.1	type B 50S ribosomal protein L36	-
XJ20_RS18390	3924475..3925353	-	879	WP_020825520.1	metal ABC transporter substrate-binding protein	-
XJ20_RS18395	3925379..3926236	-	858	WP_041414279.1	metal ABC transporter permease	-
XJ20_RS18400	3926223..3926945	-	723	WP_046374340.1	ABC transporter ATP-binding protein	-
XJ20_RS26135	3926942..3927088	-	147	WP_020825517.1	hypothetical protein	-
XJ20_RS18405	3927418..3927744	+	327	WP_041415232.1	hypothetical protein	-
XJ20_RS18410	3927907..3928275	+	369	WP_020825515.1	Hha toxicity modulator TomB	Antitoxin
XJ20_RS18415	3928313..3928534	+	222	WP_197821222.1	hemolysin expression modulator Hha	Toxin
XJ20_RS18420	3928611..3929543	-	933	WP_020825513.1	LysR family transcriptional regulator	-
XJ20_RS18425	3929682..3931469	+	1788	WP_046374341.1	adenine deaminase	-
XJ20_RS18430	3931634..3932977	+	1344	WP_020825511.1	NCS2 family permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3927391..3937588	10197

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (14-70)

Antitoxin

• Biofilm formation regulator YbaJ (1-118)

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8727.21 Da
• Isoelectric Point: 7.9877

>T53802 WP_197821222.1 NZ_CP011303:3928313-3928534 [Serratia liquefaciens]
ITPKVIMTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Nucleotide

• Length: 222 bp

>T53802 NZ_CP011303:3928313-3928534 [Serratia liquefaciens]
ATAACACCAAAGGTTATCATGACTAAAACTGATTATCTGATGCGTTTACGTAAATGCACCACTATTGACACCCTTGAACG
CGTTATTGAAAAAAATAAGTATGAGCTTTCGGATGACGAATTGGAGCTGTTTTACTCTGCAGCTGACCACCGTCTGGCTG
AGCTCACCATGAATAAGCTCTACGATAAAATCCCAACGGCCGTTTGGAAGTTCGTACGTTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14189.89 Da
• Isoelectric Point: 4.5140

>AT53802 WP_020825515.1 NZ_CP011303:3927907-3928275 [Serratia liquefaciens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEGICTTMKS

Nucleotide

• Length: 369 bp

>AT53802 NZ_CP011303:3927907-3928275 [Serratia liquefaciens]
ATGGATGAGTATTCGCCTAAAAGGCACGATATTGCTCAGCTGAAATTCTTGTGCGAAAATTTGTATGATGAAGGCATAGC
CACGCTGGGCGACAGCCACCACGGCTGGGTGAACGACCCAACGTCTTCCGTCAACCTCCAGCTTAATGAGTTGATTGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAAAGTGATTTATCGGAGTTAGTCGAGGAATATCTC
GATGATACCTACACGCTGTTCAGCAGTTACGGTATCAATGATTCCGATCTGCGTCGCTGGCAAAAAACCAAGGCGCGATT
ATTCAGAATGTTCTCAGGAGAGGGCATCTGTACGACAATGAAATCTTAG

Structures

Antitoxin

• AlphaFold DB: A0A379ZYL8