Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1907681..1908306 Replicon chromosome
Accession NZ_CP011303
Organism Serratia liquefaciens strain HUMV-21

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag XJ20_RS08910 Protein ID WP_046373265.1
Coordinates 1908124..1908306 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag XJ20_RS08905 Protein ID WP_046373264.1
Coordinates 1907681..1908094 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XJ20_RS08875 1902906..1903628 + 723 WP_020827491.1 RNA polymerase sigma factor FliA -
XJ20_RS08880 1903687..1904196 + 510 WP_041414695.1 flagella biosynthesis regulatory protein FliZ -
XJ20_RS08885 1904324..1905316 + 993 WP_046373261.1 D-cysteine desulfhydrase -
XJ20_RS08890 1905431..1906231 + 801 WP_046373262.1 cystine ABC transporter substrate-binding protein -
XJ20_RS08895 1906231..1906893 + 663 WP_020827487.1 cystine ABC transporter permease -
XJ20_RS08900 1906897..1907649 + 753 WP_046373263.1 L-cystine ABC transporter ATP-binding protein YecC -
XJ20_RS08905 1907681..1908094 - 414 WP_046373264.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
XJ20_RS08910 1908124..1908306 - 183 WP_046373265.1 type II toxin-antitoxin system HicA family toxin Toxin
XJ20_RS08915 1908473..1912444 - 3972 WP_046373266.1 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6768.95 Da        Isoelectric Point: 10.7801

>T53793 WP_046373265.1 NZ_CP011303:c1908306-1908124 [Serratia liquefaciens]
VKSSELIGLLEQEGWVLTRLKGSHHQFKHPNSRLVITVPHPRKDLKAGTLRQIMKDAGLC

Download         Length: 183 bp

>T53793 NZ_CP011303:c1908306-1908124 [Serratia liquefaciens]
GTGAAAAGTTCAGAACTGATCGGGCTATTAGAACAGGAAGGTTGGGTTTTAACGCGGCTCAAGGGAAGCCACCATCAGTT
TAAGCACCCGAACTCCCGGCTGGTGATCACCGTTCCACATCCGCGAAAGGATCTGAAAGCGGGGACGCTGCGCCAAATCA
TGAAAGATGCCGGATTGTGCTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15079.73 Da        Isoelectric Point: 4.8288

>AT53793 WP_046373264.1 NZ_CP011303:c1908094-1907681 [Serratia liquefaciens]
MFYPAYVHSEPDGSASGFFPDVPGCYFAGDTLDRAFDDARSALDAHFEFLSEDNQPIPGPQAVTFHLAQNNDSLNGGQWL
LVNINMDKFDGRAERINITLPHRLLNRIDSLVQQHPGYGSRSAFLAAAARNELLKAG

Download         Length: 414 bp

>AT53793 NZ_CP011303:c1908094-1907681 [Serratia liquefaciens]
ATGTTCTACCCTGCTTATGTACATTCAGAACCGGACGGCAGCGCCAGCGGCTTCTTTCCCGATGTGCCAGGCTGCTATTT
TGCCGGCGATACCCTGGACAGGGCCTTTGACGACGCCAGAAGTGCGCTGGACGCCCATTTCGAATTCTTGAGCGAAGACA
ATCAGCCCATTCCCGGCCCACAGGCCGTGACCTTTCATCTGGCACAGAATAACGACAGTCTGAATGGCGGACAGTGGTTG
TTGGTCAATATTAATATGGATAAGTTTGATGGTCGGGCGGAGCGTATCAATATTACCTTGCCGCACCGTCTGCTGAACCG
CATAGATTCTCTGGTGCAGCAGCATCCCGGTTACGGTAGCCGCAGCGCCTTTTTGGCCGCCGCCGCCCGCAATGAATTAT
TGAAAGCCGGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References